Protein Alignment Sh and KCNS2

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 154/514 - (29%)
• Similarity: 251/514 - (48%)
• Gaps: 137/514 - (26%)

  Fly   101 INVSGLRFETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAI 152
            |||.|.:...:..||.:||:|.||    ||..             :|.::.|::|||:...|..:
Human    21 INVGGFKRRLRSHTLLRFPETRLG----RLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYV 81

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDE--GFIKEEERPLPDNEK------ 209
            |::|.: |:|.....:.:..||:||:::     .||:|..|.  .:.....:..|:.||
Human    82 LHFYHT-GKLHVMAELCVFSFSQEIEYW-----GINEFFIDSCCSYSYHGRKVEPEQEKWDEQSD 140

  Fly   210 -----------------------------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFC 245
                                         :|::||..:.|..|..:||.:|:|:.|::.||:..|
Human   141 QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMC 205

  Fly   246 LETLPEFKHYKVFNTTTNGTKIEEDEVPDI-----TDP-FFLIETLCIIWFTFELTVRFLACPNK 304
            |.:||:|                  ::||.     .|| |.::|...|.||||||..||...|:.
Human   206 LNSLPDF------------------QIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDF 252

  Fly   305 LNFCRDVMNVIDIIAIIPYFITL-ATVVAEEEDTL-NLPKAPVSPQDKSSNQAMSLAILRVIRLV 367
            |.|.::.:|:||:::|:|::||| ..:|.|...|| ||.:                 :.:|:||:
Human   253 LKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGR-----------------VAQVLRLM 300

  Fly   368 RVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDG 432
            |:|||.||:|||.||:.||.|||.|.:|:|||:.:|.:|:.:||...|..|. .::....:||..
Human   301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEK-EENEGLATIPAC 364

  Fly   433 FWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            :|||.|:||||||||:.|....||:..|.|.:||:|.:.||:.:|.:.|::||.|   |::::|.
Human   365 WWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRR---QKQLESA 426

  Fly   498 NFNHVTSCPYLPGTLGQHMKK---------------------SSLSESSSDMMDLDDGV 535
                :.||.:     |..||:                     :::|.||...:.|:|.:
Human   427 ----MRSCDF-----GDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	27/98 (28%)
		BTB	99..182	CDD:197585	27/93 (29%)
		Ion_trans	274..488	CDD:278921	89/221 (40%)
		Ion_trans_2	403..479	CDD:285168	31/75 (41%)
KCNS2	NP_065748.1	BTB_2	19..118	CDD:308049	31/106 (29%)
		Ion_trans	186..421	CDD:306908	103/273 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810