Protein Alignment Sh and KCNS2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 156/514 - (30%)
• Similarity: 251/514 - (48%)
• Gaps: 137/514 - (26%)

  Fly   101 INVSGLRFETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAI 152
            |||.|.:...:..||.:||:|.||    ||..             :|.::.|::|||:...|..:
Human    21 INVGGFKRRLRSHTLLRFPETRLG----RLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYV 81

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDE--GFIKEEERPLPDNEK------ 209
            |::|.: |:|.....:.:..||:||:::     .||:|..|.  .:.....:..|:.||
Human    82 LHFYHT-GKLHVMAELCVFSFSQEIEYW-----GINEFFIDSCCSYSYHGRKVEPEQEKWDEQSD 140

  Fly   210 -----------------------------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFC 245
                                         :|::||..:.|..|..:||.:|:|:.|::.||:..|
Human   141 QESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMC 205

  Fly   246 LETLPEFKHYKVFNTTTNGTKIEEDEVPDI-----TDP-FFLIETLCIIWFTFELTVRFLACPNK 304
            |.:||:|                  ::||.     .|| |.::|...|.||||||..||...|:.
Human   206 LNSLPDF------------------QIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDF 252

  Fly   305 LNFCRDVMNVIDIIAIIPYFITL-ATVVAEEEDTL-NLPKAPVSPQDKSSNQAMSLAILRVIRLV 367
            |.|.::.:|:||:::|:|::||| ..:|.|...|| ||.:                 :.:|:||:
Human   253 LKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGR-----------------VAQVLRLM 300

  Fly   368 RVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDA 432
            |:|||.||:|||.||:.||.|||.|.:|:|||:.:|.:|:.:||...|..|. .||....:||..
Human   301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEK-EENEGLATIPAC 364

  Fly   433 FWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            :|||.|:||||||||:.|....||:..|.|.:||:|.:.||:.:|.:.|::||.|   |::::|.
Human   365 WWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRR---QKQLESA 426

  Fly   498 NFNHVTSCPYLPGTLGQHMKK---------------------SSLSESSSDMMDLDDGV 535
                :.||.:     |..||:                     :::|.||...:.|:|.:
Human   427 ----MRSCDF-----GDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	38/171 (22%)
		Ion_trans	226..488	CDD:459842	104/269 (39%)
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	31/112 (28%)
		Ion_trans	186..421	CDD:459842	105/273 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)