Protein Alignment Sh and KCNS1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_002242.2
• Gene: KCNS1 / 3787
• HGNCID: 6300
• Length: 526
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 151/499 - (30%)
• Similarity: 246/499 - (49%)
• Gaps: 74/499 - (14%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG--------DPARRL-RYFDPLRNEYFFDRSRPSFDAI 152
            |.:.:||.|:|.:...|.|.:||.|.||        :.|||| ..:|....|::|||....|.::
Human    50 EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSL 114

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI----------NKFREDEGFIKEEER----- 202
            |::|:: |.|.....:.:..|.:|..::.||:.|:          .:..:...:.::.:.
Human   115 LHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVD 178

  Fly   203 PLPD-----------------NEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLP 250
            |.||                 ...:|::||..|.|..|..:::.:.:|:.|:|.||...|:.:||
Human   179 PCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLP 243

  Fly   251 EFKHYKVFNTTTNGTKIEEDEVPD--ITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
            |   |:..........:.....|:  ..||.. .:|..||.||:||::.|.|..|:..||....:
Human   244 E---YQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPL 305

  Fly   313 NVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLA-ILRVIRLVRVFRIFKLS 376
            |:|||::::|:::||.              |.|:..|:...:...|. :::|.||:|:||:.||:
Human   306 NLIDIVSVLPFYLTLL--------------AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLA 356

  Fly   377 RHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMT 441
            |||.||:.||.|||.|.||:|:|:.:|.:||.:||...|.||. .|:..|.:||..:||..|:||
Human   357 RHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK-EEDVGFNTIPACWWWGTVSMT 420

  Fly   442 TVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE----EMQSQNFNHV 502
            ||||||:.||.|.||:..|.|.:.|:|.:|||:.:|.:.|::||.|:...|    ....|.|..:
Human   421 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDL 485

  Fly   503 TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHP 546
            .|.  :.|.....::.|..:.......||:....|.|    .||
Human   486 LSS--IDGVSEASLETSRETSQEGQSADLESQAPSEP----PHP 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	39/166 (23%)
		Ion_trans	226..488	CDD:459842	98/265 (37%)
KCNS1	NP_002242.2	BTB_POZ_Kv9_KCNS	52..157	CDD:349692	30/105 (29%)
		Ion_trans	219..468	CDD:459842	99/266 (37%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..526		7/35 (20%)