DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and KCNS1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_016883335.1	Gene:	KCNS1 / 3787	HGNCID:	6300	Length:	527	Species:	Homo sapiens

Alignment Length:	499	Identity:	151/499 - (30%)
Similarity:	245/499 - (49%)	Gaps:	74/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG--------DPARRL-RYFDPLRNEYFFDRSRPSFDAI 152
            |.:.:||.|:|.:...|.|.:||.|.||        :.|||| ..:|....|::|||....|.::
Human    51 EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSL 115

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI----------NKFREDEGFIKEEER----- 202
            |::|:: |.|.....:.:..|.:|..::.||:.|:          .:..:...:.::.:.
Human   116 LHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVD 179

  Fly   203 PLPD-----------------NEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLP 250
            |.||                 ...:|::||..|.|..|..:::.:.:|:.|:|.||...|:.:||
Human   180 PCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLP 244

  Fly   251 EFKHYKVFNTTTNGTKIEEDEVPD--ITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
            |   |:..........:.....|:  ..||.. .:|..||.||:||::.|.|..|:..||....:
Human   245 E---YQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPL 306

  Fly   313 NVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLA-ILRVIRLVRVFRIFKLS 376
            |:|||::::|:::||.              |.|:..|:...:...|. :::|.||:|:||:.||:
Human   307 NLIDIVSVLPFYLTLL--------------AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLA 357

  Fly   377 RHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMT 441
            |||.||:.||.|||.|.||:|:|:.:|.:||.:||...|.||...|.. |.:||..:||..|:||
Human   358 RHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMT 421

  Fly   442 TVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE----EMQSQNFNHV 502
            ||||||:.||.|.||:..|.|.:.|:|.:|||:.:|.:.|::||.|:...|    ....|.|..:
Human   422 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDL 486

  Fly   503 TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHP 546
            .|.  :.|.....::.|..:.......||:....|.|    .||
Human   487 LSS--IDGVSEASLETSRETSQEGQSADLESQAPSEP----PHP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	29/96 (30%)
		BTB	99..182	CDD:197585	27/91 (30%)
		Ion_trans	274..488	CDD:278921	87/217 (40%)
		Ion_trans_2	403..479	CDD:285168	36/75 (48%)
KCNS1	XP_016883335.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810