Protein Alignment Sh and KCNQ1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_000209.2
• Gene: KCNQ1 / 3784
• HGNCID: 6294
• Length: 676
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 96/392 - (24%)
• Similarity: 152/392 - (38%)
• Gaps: 85/392 - (21%)

  Fly   197 IKEEERP-LPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNT 260
            |....|| |.....|.:|:...|.|...:.  .|...:||:|:|..:||  ..|...:.|....|
Human    93 IYSTRRPVLARTHVQGRVYNFLERPTGWKC--FVYHFAVFLIVLVCLIF--SVLSTIEQYAALAT 153

  Fly   261 TTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRF--LACPNK-------LNFCRDVMNVID 316
            .|                .|.:|.:.:::|..|..||.  ..|.:|       |.|.|..:::||
Human   154 GT----------------LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIID 202

  Fly   317 IIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKG 381
            :|.::...:.|..                    .|..|..:.:.:|.||.:::.|:..:.|....
Human   203 LIVVVASMVVLCV--------------------GSKGQVFATSAIRGIRFLQILRMLHVDRQGGT 247

  Fly   382 LQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSF----FKSIPDAFWWAVVTMTT 442
            .::||..:....:||...::..|:|::..|..||.||..:.|..    |.|..||.||.|||:||
Human   248 WRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTT 312

  Fly   443 VGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ---------- 497
            :||||..|....||.:.|..::..:...|||..::.|.|.....::..|:....|
Human   313 IGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQT 377

  Fly   498 --------NFNHVTSCPYLPGTLGQHM--------KKSSLSESSSDMMDLDDGVESTPG---LTE 543
                    |.:..|...|:......|.        |||.:.:.....:|.|:||  |||   ||.
Human   378 AWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGV--TPGEKMLTV 440

  Fly   544 TH 545
            .|
Human   441 PH 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	8/26 (31%)
		Ion_trans	226..488	CDD:459842	69/274 (25%)
KCNQ1	NP_000209.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..84
		Ion_trans	123..359	CDD:459842	69/273 (25%)
		Interaction with KCNE3. /evidence=ECO:0000269|PubMed:31883792	238..246		1/7 (14%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:25441029	370..382		0/11 (0%)
		KCNQ_channel	<511..617	CDD:460954
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000269|PubMed:25441029	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000269|PubMed:25037568	535..572
		Interaction with AKAP9. /evidence=ECO:0000269|PubMed:11799244	588..616
		C-terminal assembly domain (tetramerization). /evidence=ECO:0000269|PubMed:10654932	589..620
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..676