DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCNK2

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001017425.2 Gene:KCNK2 / 3776 HGNCID:6277 Length:426 Species:Homo sapiens


Alignment Length:350 Identity:72/350 - (20%)
Similarity:113/350 - (32%) Gaps:131/350 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 ERP-------LPD---------NEKQR-----KVWLLFEYPESSQAARVVAIISVFVILLSIVIF 244
            |||       .||         |.|.|     |..:|....||.....|:...:|..|.|.:|::
Human     8 ERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLY 72

  Fly   245 CLETLPEFK----HYKVFNTTT---------------NGTKIEE-----------DEVP------ 273
            .:.....||    .:::...||               |.|:::|           ..:|      
Human    73 LIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSN 137

  Fly   274 -----DITDPFFLIETLCIIWFTFELTVRFLACPNKLN----FCRDVMNVIDIIAIIPYFITLAT 329
                 |:...||...|:.       .|:.|.....:..    ||     :|..:..||.|..|..
Human   138 QISHWDLGSSFFFAGTVI-------TTIGFGNISPRTEGGKIFC-----IIYALLGIPLFGFLLA 190

  Fly   330 VVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMR 394
            .|.::..|: ..|.....:|......:|...:|:|                              
Human   191 GVGDQLGTI-FGKGIAKVEDTFIKWNVSQTKIRII------------------------------ 224

  Fly   395 ELGLLIFFLFIGVVLFSS--AVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVG----- 452
              ..:||.|| |.|||.:  |:.|......::.     ||.::.|:|:||:|:||....|     
Human   225 --STIIFILF-GCVLFVALPAIIFKHIEGWSAL-----DAIYFVVITLTTIGFGDYVAGGSDIEY 281

  Fly   453 -------VWGKIVGSLCAIAGVLTI 470
                   ||..|:..|...|.||::
Human   282 LDFYKPVVWFWILVGLAYFAAVLSM 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 11/42 (26%)
Ion_trans 226..488 CDD:459842 60/303 (20%)
KCNK2NP_001017425.2 Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 17..38 5/20 (25%)
Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 51..61 1/9 (11%)
Ion_trans_2 <138..196 CDD:462301 14/69 (20%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6 157..162 2/4 (50%)
Ion_trans_2 234..312 CDD:462301 22/77 (29%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6 266..271 2/4 (50%)
Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438 313..326
Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438 337..385
Blue background indicates that the domain is not in the aligned region.

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