Protein Alignment Sh and KCNG1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_002228.2
• Gene: KCNG1 / 3755
• HGNCID: 6248
• Length: 513
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 156/529 - (29%)
• Similarity: 244/529 - (46%)
• Gaps: 99/529 - (18%)

  Fly    53 QRNSLDG--YGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTL 115
            ||.::.|  |....:|..|||.          .|..:|    .|...|::|||.|:::.....||
Human    31 QRQAIKGAFYRRAQRLRPQDEP----------RQGCQP----EDRRRRIIINVGGIKYSLPWTTL 81

  Fly   116 NQFPDTLLGDPARRLRYFDPLR---------NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLD 171
            ::||.|.||.......:.|.|.         ||:||||:..:|..||.:.:: |:||....:...
Human    82 DEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRA-GKLRLLREMCAL 145

  Fly   172 VFSEEIKFYELGD------------QAINKFREDEGFIKEEERPLPDNEKQ-------------- 210
            .|.||:.::.:.:            |.|.:|.  |...:|||....|:|.:
Human   146 SFQEELLYWGIAEDHLDGCCKRRYLQKIEEFA--EMVEREEEDDALDSEGRDSEGPAEGEGRLGR 208

  Fly   211 --RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVP 273
              |::..:.|.|.|....:|.|.:||..:.::.|...:.|||..:..:           |:....
Human   209 CMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEE-----------EQGHCS 262

  Fly   274 DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTL 338
            .:....|::|::|:.||:.|..:|.:..|:|..|.|..:.:||::||:||:|||  :|.......
Human   263 QMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITL--LVDGAAAGR 325

  Fly   339 NLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFL 403
            ..|.|..|..||..      .:|||:|.:|:..:.:|:|||.|||.||.|.:...||.|||:.||
Human   326 RKPGAGNSYLDKVG------LVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFL 384

  Fly   404 FIGVVLFSSAVYFAE-AGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGV 467
            .:.:.||:..:|..| ..:::..|.|||..:||||:||||||||||.|....|::|.....::|:
Human   385 CVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGI 449

  Fly   468 LTIALPVPVIVSNFNYFY-HRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSES------- 524
            |.:|.||..|...|:..| ..:.:||.:..:.      ..:|..|      ||.||.|
Human   450 LLMAFPVTSIFHTFSRSYLELKQEQERVMFRR------AQFLIKT------KSQLSVSQDSDILF 502

  Fly   525 ---SSDMMD 530
               |||..|
Human   503 GSASSDTRD 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	41/162 (25%)
		Ion_trans	226..488	CDD:459842	90/263 (34%)
KCNG1	NP_002228.2	BTB_POZ_KCNG1_2	60..173	CDD:349728	31/113 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..204		4/19 (21%)
		Ion_trans	227..471	CDD:459842	90/262 (34%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)