DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sh and KCNF1

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_002227.2 Gene:KCNF1 / 3754 HGNCID:6246 Length:494 Species:Homo sapiens


Alignment Length:472 Identity:149/472 - (31%)
Similarity:239/472 - (50%) Gaps:96/472 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LDGYG--SLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFP 119
            :||.|  |||:..||.....                   |..| :|:||.|:|.......|:|:|
Human     1 MDGSGERSLPEPGSQSSAAS-------------------DDIE-IVVNVGGVRQVLYGDLLSQYP 45

  Fly   120 DTLLGDPARRLR--Y---------FDPLRNEYFFDRSRPSFDAIL--YYYQSGGRLRRPVNVPLD 171
            :|.|.:....|.  |         :||.:.|::|||...:|..::  ||:   |.:.....:...
Human    46 ETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYF---GEVHMKKGICPI 107

  Fly   172 VFSEEIKFYELGDQAINKFRED--EGFIKEEERPLPDNEK---------------------QRKV 213
            .|..|:.|:::.    .||.:|  :..:.|:...|.:..:                     |:.|
Human   108 CFKNEMDFWKVD----LKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCV 168

  Fly   214 WLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDP 278
            |...|.||||..|||||::|..:||:|.|:.|:.|:||.   :|.:  ..|.::|...:.:    
Human   169 WKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPEL---QVLD--AEGNRVEHPTLEN---- 224

  Fly   279 FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFI--TLATVVAEEEDTLNLP 341
               :||.||.|||.|..:|..:.||||:|....||::|::||:|:::  ||..:.|...:..|:.
Human   225 ---VETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQ 286

  Fly   342 KAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIG 406
            :|                 ::.:|::|:.|||||:|||.|||.|...||.|.:|||||:.:|.:|
Human   287 QA-----------------VQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVG 334

  Fly   407 VVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIA 471
            :.:||:..|..|.....:.|||||.:||||::|||||||||:.|....||:..::..:.||:.||
Human   335 IFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIA 399

  Fly   472 LPVPVIVSNFNYFYHRE 488
            ||:..|::||..:|:::
Human   400 LPIHPIINNFVRYYNKQ 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 37/161 (23%)
Ion_trans 226..488 CDD:459842 101/263 (38%)
KCNF1NP_002227.2 BTB_POZ_Kv5_KCNF1 23..138 CDD:349690 30/122 (25%)
Ion_trans 181..417 CDD:459842 101/265 (38%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..469
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.