DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and KCND3

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001365898.1	Gene:	KCND3 / 3752	HGNCID:	6239	Length:	655	Species:	Homo sapiens

Alignment Length:	575	Identity:	185/575 - (32%)
Similarity:	293/575 - (50%)	Gaps:	102/575 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.||:|...||.::||||||...:.. :|:....||||||....|..:|.:|:: |:
Human    40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GK 102

  Fly   162 LRRPVNVPLDVFSEEIKFYE-----LGDQAINKFREDEGFIKEEERPLPDNEKQ----------- 210
            |..|....:..:.:|:.||.     :||....::::.:.  :..||.:.||:.:
Human   103 LHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKR--ENAERLMDDNDSENNQESMPSLSF 165

  Fly   211 -RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVP- 273
             :.:|..||.|.:|..|.|...::.|.|.:|::...:||:|        ..|..|:|    |:|
Human   166 RQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------CGTVPGSK----ELPC 218

  Fly   274 --DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEED 336
              ..:..||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.
Human   219 GERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLV-------- 275

  Fly   337 TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIF 401
                         .::|:.:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|
Human   276 -------------MTNNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLF 326

  Fly   402 FLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAG 466
            .|.:.:::|::.:::||.||.:|.|.|||..||:.:|||||:|||||.|..:.|||.||:|:::|
Human   327 SLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSG 391

  Fly   467 VLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHV---------TSCPYLPGTLGQHMKKSSLS 522
            ||.||||||||||||:..||:....::.::|....:         :|..||      |.|::.|
Human   392 VLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYL------HSKRNGL- 449

  Fly   523 ESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQT 587
                    |::.:|.|....|.|.|::                 :||..|....|.|.|::.|..
Human   450 --------LNEALELTGTPEEEHMGKT-----------------TSLIESQHHHLLHCLEKTTGL 489

  Fly   588 QLYQQQQQQQQQQQNGFKQQQQQTQQQLQQ--QQSHTINASAAAATSGSGSSGLT 640
            . |.........:.:..|..:...:|..:|  .:|...|..:..:.|.|...|||
Human   490 S-YLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	34/92 (37%)
		BTB	99..182	CDD:197585	32/87 (37%)
		Ion_trans	274..488	CDD:278921	97/213 (46%)
		Ion_trans_2	403..479	CDD:285168	41/75 (55%)
KCND3	NP_001365898.1	Interaction with KCNIP2. /evidence=ECO:0000250	2..20
		BTB_POZ_KCND3	6..143	CDD:349726	35/106 (33%)
		Ion_trans	186..412	CDD:395416	107/259 (41%)
		Selectivity filter. /evidence=ECO:0000250	367..372		3/4 (75%)
		DUF3399	442..563	CDD:403174	28/135 (21%)
		Mediates dendritic targeting. /evidence=ECO:0000250	472..487		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..565		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810