DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCND2

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_036413.1 Gene:KCND2 / 3751 HGNCID:6238 Length:630 Species:Homo sapiens


Alignment Length:596 Identity:182/596 - (30%)
Similarity:286/596 - (47%) Gaps:143/596 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLR 163
            :|:||||.||:|...||.::||||||...|.. ::.|...:|||||....|..||.:|:: |:|.
Human    43 IVLNVSGTRFQTWQDTLERYPDTLLGSSERDF-FYHPETQQYFFDRDPDIFRHILNFYRT-GKLH 105

  Fly   164 RPVNVPLDVFSEEIKFYEL-----GDQAINKF----REDEGFIKEE-------ERPLPDNEKQRK 212
            .|.:..:..:.||:.|:.|     ||....::    ||:...::::       |..||....:::
Human   106 YPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQR 170

  Fly   213 VWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLP---EFKHYKVFNTTTNGTKIEEDEVP- 273
            ||..||.|.:|..|.|...::.|.|.:|::...:||:|   ...|.|              |:| 
Human   171 VWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIK--------------ELPC 221

  Fly   274 --DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEED 336
              .....||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|  |:.:.||
Human   222 GERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGL--VMTDNED 284

  Fly   337 TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIF 401
                               :|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|
Human   285 -------------------VSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLF 329

  Fly   402 FLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAG 466
            .|.:.:::|::.:::||.||.:|.|.|||..||:.:|||||:|||||.|..:.|||.||:|:::|
Human   330 SLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSG 394

  Fly   467 VLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDL 531
            ||.||||||||||||:..||:....::.::|                   ||:.|:.        
Human   395 VLVIALPVPVIVSNFSRIYHQNQRADKRRAQ-------------------KKARLAR-------- 432

  Fly   532 DDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQ 596
                                             :.::.|.|.:..:|.....|...||...:.:|
Human   433 ---------------------------------IRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQ 464

  Fly   597 QQQQQNG--FKQQQQQTQQQLQQQQSH----------------TINASAAAATSGSGSSGLT--- 640
            ....::|  |:.|.......|::..:|                |:|..::.:.|.|...|:|   
Human   465 AFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTC 529

  Fly   641 --MRHNNALAV 649
              .||.....:
Human   530 CSRRHKKTFRI 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 36/92 (39%)
BTB 99..182 CDD:197585 33/82 (40%)
Ion_trans 274..488 CDD:278921 99/213 (46%)
Ion_trans_2 403..479 CDD:285168 41/75 (55%)
KCND2NP_036413.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
Shal-type 3..28 CDD:288455
BTB_2 43..132 CDD:308049 35/90 (39%)
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90 7/19 (37%)
Ion_trans 184..415 CDD:306908 110/266 (41%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 3/4 (75%)
DUF3399 445..546 CDD:314709 18/96 (19%)
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482 474..630 12/67 (18%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..630
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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