Protein Alignment Sh and KCND1

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_024308146.1
• Gene: KCND1 / 3750
• HGNCID: 6237
• Length: 675
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 183/581 - (31%)
• Similarity: 286/581 - (49%)
• Gaps: 113/581 - (19%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.||||...||:::||||||...:.. ::|....||||||....|..:|.:|:: ||
Human    40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GR 102

  Fly   162 LRRPVNVPLDVFSEEIKFYEL-----GDQAINKFREDEGFIKEEERPLPDNEK------------ 209
            |..|....:..|.||:.||.|     ||..:.::|:.:   ||....|.::|:
Human   103 LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK---KENAERLAEDEEAEQAGDGPALPA 164

  Fly   210 ----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEED 270
                ::::|..||.|.:|.||.|...::.|.|.:|::...:||:|          .....:....
Human   165 GSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP----------CRGSARRSSR 219

  Fly   271 EVP---DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVA 332
            |.|   .....||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.
Human   220 EQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLL---- 280

  Fly   333 EEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELG 397
                   :||          |..:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||
Human   281 -------VPK----------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 327

  Fly   398 LLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLC 462
            .|:|.|.:.:::|::.:::||.|::.:.|.|||..||:.:|||||:|||||.|..:.|||.||:|
Human   328 FLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSIC 392

  Fly   463 AIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSD 527
            :::|||.||||||||||||:..||:....::.::|.              ...:.:..|::|.:.
Human   393 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQ--------------KVRLARIRLAKSGTT 443

  Fly   528 MMDL----DDGVESTPGLTE---THPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLT 585
            ...|    :.|:|...||..   :|.|....|..                         .|..|.
Human   444 NAFLQYKQNGGLEVGRGLDRVGVSHNGEEGAALI-------------------------ALLHLL 483

  Fly   586 QTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQSH------TINASAAAATSGSGSSGLT 640
            |.....::|....:.::.|:||.......|::...|      |.:.:..|.:.|..:|..|
Human   484 QDSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRST 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	39/92 (42%)
		BTB	99..182	CDD:197585	36/82 (44%)
		Ion_trans	274..488	CDD:278921	97/213 (46%)
		Ion_trans_2	403..479	CDD:285168	39/75 (52%)
KCND1	XP_024308146.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:308049	38/90 (42%)
		Ion_trans	185..417	CDD:306908	106/263 (40%)
		DUF3399	447..578	CDD:314709	22/123 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810