Protein Alignment Sh and KCNC4

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_024302558.1
• Gene: KCNC4 / 3749
• HGNCID: 6236
• Length: 661
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 191/582 - (32%)
• Similarity: 273/582 - (46%)
• Gaps: 162/582 - (27%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDT---LLGDPARRLRYFDPLRN---------------EYFFD 143
            |:::|||.|.|.||...||...|.|   .|.||....|   |..:               |:|||
Human    36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PETDGGGVGSSGSSGGGGCEFFFD 97

  Fly   144 RSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYEL------------------GDQAINKF 190
            |....|..:|.||:: |:|..|.:|...:|.||:.|:.:                  .::|::.|
Human    98 RHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIF 161

  Fly   191 REDEG---------FIKEEERPLPDNEK-------------------QRKVWLLFEYPESSQAAR 227
            ...:|         ...::||.|.....                   |.::|.|||.|.||:|||
Human   162 ESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAAR 226

  Fly   228 VVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFF-----------L 281
            |||..|:|.||:||..|||||      ::.||...|.|:|.  .|.:||...|           .
Human   227 VVAFASLFFILVSITTFCLET------HEAFNIDRNVTEIL--RVGNITSVHFRREVETEPILTY 283

  Fly   282 IETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVS 346
            ||.:|::|||.|..||.:.||:.|:|.::::|:||.:||:|:::                  .|.
Human   284 IEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYL------------------EVG 330

  Fly   347 PQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLF 410
            ....||..|.. |..|||:|.||:.|||||:||..||::||.||:||..|..|||.||.:||::|
Human   331 LSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 395

  Fly   411 SSAVYFAE---------AGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAG 466
            ::.:|:||         .|::::.||:||..||||||||||:|||||.|....|.:||:|||:||
Human   396 ATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAG 460

  Fly   467 VLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDL 531
            |||||:||||||:||..:|.....::::..:...||.....|...:  :.|....|...|...|.
Human   461 VLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPM--YCKSEETSPRDSTCSDT 523

  Fly   532 -----DDGV--------------------ESTPGLTETHPGRSAVAPFLGAQQQQQQPVASS 568
                 ::|:                    |...|||                    ||:|||
Human   524 SPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLT--------------------QPLASS 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	46/189 (24%)
		Ion_trans	226..488	CDD:459842	125/282 (44%)
KCNC4	XP_024302558.1	Potassium_chann	1..29	CDD:431870
		BTB_KCNC2_4	35..158	CDD:349722	34/125 (27%)
		Ion_trans	225..483	CDD:459842	125/283 (44%)