DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCNC3

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens


Alignment Length:583 Identity:194/583 - (33%)
Similarity:274/583 - (46%) Gaps:152/583 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 HGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLG---DPARRLRY-FDPLR 137
            ||.|||..            .::||||.|:|.||...||...|.|.|.   :|....|: :||..
Human    80 HGGGGGDS------------GKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGA 132

  Fly   138 NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI--------NKFREDE 194
            :|:||||....|..:|.||:: |:|..|.:|...:|.||:.|:.:.:..:        .:.|:.|
Human   133 DEFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE 196

  Fly   195 GFIKEEERPLP-----------------DNEK--------------------------------- 209
            ..:...|.|.|                 |:|.                                 
Human   197 EALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261

  Fly   210 -----------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTT- 262
                       |.:||.|||.|.||:|||.||..|:|.||:||..|||||...|.|  :.|.|. 
Human   262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIH--ISNKTVT 324

  Fly   263 -----------NGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVI 315
                       |.|.:|.:     |:||. .:|.:|::|||||..:|...||:|:.|.:..:|:|
Human   325 QASPIPGAPPENITNVEVE-----TEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNII 384

  Fly   316 DIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHS 379
            |.:||:|:::                  .|.....||..|.. |..|||:|.||:.|||||:||.
Human   385 DCVAILPFYL------------------EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHF 431

  Fly   380 KGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSDSSFFKSIPDGFWW 435
            .||::||.||:||..|..|||.||.:||::|::.:|:||         .||:.::||:||.||||
Human   432 VGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWW 496

  Fly   436 AVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFN 500
            |||||||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....::::..:...
Human   497 AVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNK 561

  Fly   501 HVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLT----------------ETHPG 547
            |:...|. ||: ..:.|................|:...|.:|                .||||
Human   562 HIPRPPQ-PGS-PNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPG 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 34/91 (37%)
BTB 99..182 CDD:197585 34/86 (40%)
Ion_trans 274..488 CDD:278921 104/224 (46%)
Ion_trans_2 403..479 CDD:285168 48/84 (57%)
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87 5/6 (83%)
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:314363
BTB_KCNC1_3 89..202 CDD:349721 36/113 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232 2/21 (10%)
Ion_trans 289..550 CDD:366146 126/285 (44%)
Selectivity filter. /evidence=ECO:0000250 503..508 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 8/58 (14%)
PHA03247 <637..752 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.810

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