DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCNC3

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_004968.2 Gene:KCNC3 / 3748 HGNCID:6235 Length:757 Species:Homo sapiens


Alignment Length:583 Identity:193/583 - (33%)
Similarity:273/583 - (46%) Gaps:152/583 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 HGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLG---DPARRLRY-FDPLR 137
            ||.|||..            .::||||.|:|.||...||...|.|.|.   :|....|: :||..
Human    80 HGGGGGDS------------GKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGA 132

  Fly   138 NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI--------NKFREDE 194
            :|:||||....|..:|.||:: |:|..|.:|...:|.||:.|:.:.:..:        .:.|:.|
Human   133 DEFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE 196

  Fly   195 GFIKEEERPLP-----------------DNEK--------------------------------- 209
            ..:...|.|.|                 |:|.                                 
Human   197 EALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261

  Fly   210 -----------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTT- 262
                       |.:||.|||.|.||:|||.||..|:|.||:||..|||||...|.|  :.|.|. 
Human   262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIH--ISNKTVT 324

  Fly   263 -----------NGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVI 315
                       |.|.:|.:     |:||. .:|.:|::|||||..:|...||:|:.|.:..:|:|
Human   325 QASPIPGAPPENITNVEVE-----TEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNII 384

  Fly   316 DIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHS 379
            |.:||:|:::                  .|.....||..|.. |..|||:|.||:.|||||:||.
Human   385 DCVAILPFYL------------------EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHF 431

  Fly   380 KGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSENSFFKSIPDAFWW 435
            .||::||.||:||..|..|||.||.:||::|::.:|:||         .||.:::||:||..|||
Human   432 VGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWW 496

  Fly   436 AVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFN 500
            |||||||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....::::..:...
Human   497 AVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNK 561

  Fly   501 HVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLT----------------ETHPG 547
            |:...|. ||: ..:.|................|:...|.:|                .||||
Human   562 HIPRPPQ-PGS-PNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPG 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 48/198 (24%)
Ion_trans 226..488 CDD:459842 125/284 (44%)
KCNC3NP_004968.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87 5/6 (83%)
Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 1..78
Potassium_chann 1..>18 CDD:431870
BTB_KCNC1_3 89..202 CDD:349721 36/113 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..232 2/21 (10%)
Ion_trans 289..550 CDD:459842 125/285 (44%)
Selectivity filter. /evidence=ECO:0000250 503..508 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..613 8/58 (14%)
PHA03247 <637..752 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..746
Blue background indicates that the domain is not in the aligned region.

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