Protein Alignment Sh and KCNC2

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_631875.1
• Gene: KCNC2 / 3747
• HGNCID: 6234
• Length: 638
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 193/576 - (33%)
• Similarity: 271/576 - (47%)
• Gaps: 160/576 - (27%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLL----------------GD-----------PARRLRYFD 134
            |||::||.|.|.||...||...|.|.|                ||           |.|.    .
Human     8 ERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRA----P 68

  Fly   135 PLR----------------------------NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLD 171
            ||.                            .|:||||....|..:|.||:: |:|..|.:|...
Human    69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGP 132

  Fly   172 VFSEEIKFYEL------------------GDQAINKFR----------EDEGFIK-----EEERP 203
            :|.||:.|:.:                  .::|::.|.          :||....     |:...
Human   133 LFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAG 197

  Fly   204 L--PDNEK------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNT 260
            |  ||.:.      |.::|.|||.|.||:|||.:|..|:|.||:||..|||||...|...|  |.
Human   198 LGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--NK 260

  Fly   261 T---TNGTKIE-EDEVPDITDP-FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAI 320
            |   .|||.:. :.|:.  ||| ...:|.:|::|||||..||.:..||||.|.::::|:||.:||
Human   261 TEPVINGTSVVLQYEIE--TDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAI 323

  Fly   321 IPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHSKGLQI 384
            :|:::                  .|.....||..|.. |..|||:|.||:.|||||:||..||::
Human   324 LPFYL------------------EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRV 370

  Fly   385 LGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSDSSFFKSIPDGFWWAVVTM 440
            ||.||:||..|..|||.||.:||::|::.:|:||         :.|:.:.||:||.|||||||||
Human   371 LGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTM 435

  Fly   441 TTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSC 505
            ||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....::::..:...|:...
Human   436 TTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPA 500

  Fly   506 PYLPG-------------------TLGQHMKKSSLSESSSDMMDLDDGVESTPGLT 542
            |....                   .||   |.:.|.|.:..::..||...|.|.|:
Human   501 PQASSPTFCKTELNMACNSTQSDTCLG---KDNRLLEHNRSVLSGDDSTGSEPPLS 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	35/160 (22%)
		BTB	99..182	CDD:197585	35/137 (26%)
		Ion_trans	274..488	CDD:278921	105/224 (47%)
		Ion_trans_2	403..479	CDD:285168	47/84 (56%)
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	37/162 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..93		6/58 (10%)
		Ion_trans	228..484	CDD:395416	127/277 (46%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..572		5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810