Protein Alignment Sh and KCNC1

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 196/598 - (32%)
• Similarity: 285/598 - (47%)
• Gaps: 148/598 - (24%)

  Fly    94 DFCERVVINVSGLRFETQLRTLNQFPDT---LLGDPARRLRY-FDPLRNEYFFDRSRPSFDAILY 154
            |..||:||||.|.|.:|...||...|.|   .|.:|.....: :||..:|:||||....|..||.
Human     5 DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69

  Fly   155 YYQSGGRLRRPVNVPLDVFSEEIKFYEL------------------GDQAINKF----------- 190
            ||:: |:|..|.:|...::.||:.|:.:                  .::|::.|
Human    70 YYRT-GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADD 133

  Fly   191 -----------REDEGFIKEEER----PLPDNEK-------QRKVWLLFEYPESSQAARVVAIIS 233
                       .|||  ::..:|    ..||...       |.::|.|||.|.||:.||.||..|
Human   134 ADADGPGDSGDGEDE--LEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFAS 196

  Fly   234 VFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIE------------EDEVPDITDPFF-LIETL 285
            :|.||:||..|||||      ::.||...|.|:||            |.|    |:.|. .||.:
Human   197 LFFILVSITTFCLET------HERFNPIVNKTEIENVRNGTQVRYYREAE----TEAFLTYIEGV 251

  Fly   286 CIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDK 350
            |::|||||..:|.:.||||:.|.::.:|:||.:||:|:::                  .|.....
Human   252 CVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYL------------------EVGLSGL 298

  Fly   351 SSNQAMS-LAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAV 414
            ||..|.. |..|||:|.||:.|||||:||..||::||.||:||..|..|||.||.:||::|::.:
Human   299 SSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 363

  Fly   415 YFAE---------AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTI 470
            |:||         :.|:.:.||:||.|||||||||||:|||||.|....|.:||:|||:||||||
Human   364 YYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTI 428

  Fly   471 ALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYL--------------------------- 508
            |:||||||:||..:|.....::::..:...|:...|.|
Human   429 AMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQE 493

  Fly   509 --------PGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPG-RSAVAP-FLGAQQQQQQ 563
                    ...|...:.|::|  ::.|...:|..:....||..|..| |....| ||.:..:...
Human   494 EILEINRADSKLNGEVAKAAL--ANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYAC 556

  Fly   564 PVASSLSMSIDKQ 576
            |....:...:.|:
Human   557 PPGGGMRKDLCKE 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	32/109 (29%)
		BTB	99..182	CDD:197585	32/86 (37%)
		Ion_trans	274..488	CDD:278921	104/224 (46%)
		Ion_trans_2	403..479	CDD:285168	47/84 (56%)
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	35/116 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		1/25 (4%)
		Ion_trans	189..447	CDD:395416	127/285 (45%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810