DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and KCNA10

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_005540.1	Gene:	KCNA10 / 3744	HGNCID:	6219	Length:	511	Species:	Homo sapiens

Alignment Length:	511	Identity:	289/511 - (56%)
Similarity:	357/511 - (69%)	Gaps:	68/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QDEEGGA-------------GHGFGGG-------PQH---FEPIPHDH------------DFCER 98
            |:|.|.|             |..|..|       ..|   |..:|.|:            :..:|
Human    23 QEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQR 87

  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLR 163
            |:||::|||||||||||:|||:|||||..:|:::||.:||||||||:|||||.|||||||||::|
Human    88 VIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIR 152

  Fly   164 RPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARV 228
            ||.|||:|:|::||.|||||.:|:::|||||||||:.|..||.|:..|:.||||||||||.|||.
Human   153 RPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARA 217

  Fly   229 VAIISVFVILLSIVIFCLETLPEF---KHYKVF---NTTTNGTKIEEDEVPDITDPFFLIETLCI 287
            ||::||.|:::||.||||||||||   :..||.   |...:.|.:.:..   .|||||::|:.||
Human   218 VAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTM---FTDPFFMVESTCI 279

  Fly   288 IWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSS 352
            :||||||.:||:.||:|.:|.|::||:||||:|||||.||.|.:.:|             .:.|:
Human   280 VWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQE-------------TEPSA 331

  Fly   353 NQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFA 417
            .|.|||||||:|||||||||||||||||||||||:||||||||||||||||||||:|||||||||
Human   332 QQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFA 396

  Fly   418 EAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFN 482
            |.....|.|.|||||||||||||||||||||.|....|||||:||||||||||||||||||||||
Human   397 EVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFN 461

  Fly   483 YFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVEST 538
            |||||||:.||.|:           :||.:.:.:........|:|.::..:|..||
Human   462 YFYHRETENEEKQN-----------IPGEIERILNSVGSRMGSTDSLNKTNGGCST 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	62/87 (71%)
		BTB	99..182	CDD:197585	59/82 (72%)
		Ion_trans	274..488	CDD:278921	153/213 (72%)
		Ion_trans_2	403..479	CDD:285168	61/75 (81%)
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..50		6/26 (23%)
		BTB_2	88..179	CDD:308049	63/90 (70%)
		Ion_trans	255..467	CDD:306908	154/227 (68%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I953
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.890