DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sh and KCNA5

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens


Alignment Length:458 Identity:300/458 - (65%)
Similarity:347/458 - (75%) Gaps:45/458 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 PKLSSQDEEGGAGHG------FGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTL 122
            |....::|||..|.|      .|....|.          :||.||:|||||||||.||.|||:||
Human    91 PPPEDEEEEGDPGLGTVEDQALGTASLHH----------QRVHINISGLRFETQLGTLAQFPNTL 145

  Fly   123 LGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI 187
            |||||:||||||||||||||||:|||||.|||||||||||||||||.||||::||:||:|||:|:
Human   146 LGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAM 210

  Fly   188 NKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEF 252
            .:||||||||||||:|||.||.||:|||:|||||||.:||.:||:||.|||:||:.|||||||||
Human   211 ERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEF 275

  Fly   253 KHYKVF-------------NTTTNGTKIEEDE--------VP-DITDPFFLIETLCIIWFTFELT 295
            :..:..             ....||:.:....        :| .:.||||::||.|:|||||||.
Human   276 RDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELL 340

  Fly   296 VRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAI 360
            |||.|||:|..|.|::||:||::||.||||||.|.:||::     |......|  :..|||||||
Human   341 VRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQ-----PGGGGGGQ--NGQQAMSLAI 398

  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSF 425
            ||||||||||||||||||||||||||:||:|||||||||||||||||:|||||||||||.:..:.
Human   399 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTH 463

  Fly   426 FKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 490
            |.||||.||||||||||||||||||:.|.||||||||||||||||||||||||||||||||||||
Human   464 FSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 528

  Fly   491 QEE 493
            .||
Human   529 HEE 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 73/87 (84%)
BTB 99..182 CDD:197585 70/82 (85%)
Ion_trans 274..488 CDD:278921 159/213 (75%)
Ion_trans_2 403..479 CDD:285168 63/75 (84%)
KCNA5NP_002225.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108 6/16 (38%)
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_2 122..213 CDD:308049 74/90 (82%)
Ion_trans 249..526 CDD:306908 182/283 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304 2/21 (10%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559 300/458 (66%)
PDZ-binding. /evidence=ECO:0000250 611..613
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 362 1.000 Domainoid score I953
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48093
OrthoDB 1 1.010 - - D307298at33208
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - LDO PTHR11537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.790

Return to query results.
Submit another query.