DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCNA4

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens


Alignment Length:567 Identity:317/567 - (55%)
Similarity:401/567 - (70%) Gaps:65/567 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GEDRQHRKKQQQQQQHQKEQ-----------------LEQKEEQKKIAERKLQLREQQLQRNSLD 58
            |..|:.|::.::::.|.::.                 |.:..|:::..|.:.:..|:.....|.|
Human    81 GSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSED 145

  Fly    59 GYG---SLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPD 120
            .:|   |...|..|||.||.          :..:.:. |.||||||||||||||||::||.|||:
Human   146 DHGDECSYTDLLPQDEGGGG----------YSSVRYS-DCCERVVINVSGLRFETQMKTLAQFPE 199

  Fly   121 TLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQ 185
            ||||||.:|.:|||||||||||||:|||||||||||||||||:||||||.|:|:||:|||:||::
Human   200 TLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEE 264

  Fly   186 AINKFREDEGFIKEEE-RPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETL 249
            |:.||||||||::||| |.||:||.::::||||||||||..||.:||:||.|||:||||||||||
Human   265 ALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETL 329

  Fly   250 PEFK-------------HYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLAC 301
            |||:             |..:.| .|:...:|........||||::||:||:||:||..||..||
Human   330 PEFRDDRDLVMALSAGGHGGLLN-DTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFAC 393

  Fly   302 PNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRL 366
            |::..|.:::||:|||::|:||||||.|.:|:::...|          ....||||.||||:|||
Human   394 PSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGN----------GQQQQAMSFAILRIIRL 448

  Fly   367 VRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPD 431
            ||||||||||||||||||||.||:|||||||||||||||||:|||||||||||....:.|:||||
Human   449 VRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPD 513

  Fly   432 AFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQS 496
            |||||||||||||||||.|:.|.|||||||||||||||||||||||||||||||||||:.|| |:
Human   514 AFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE-QT 577

  Fly   497 QNFNHVTSCPYLPGTLGQHMKKSSLSESS-----SDMMDLDDGVEST 538
            |...:..||||||..|   :||...|.||     |:.:::::||:.:
Human   578 QLTQNAVSCPYLPSNL---LKKFRSSTSSSLGDKSEYLEMEEGVKES 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 97/126 (77%)
Ion_trans 226..488 CDD:459842 176/274 (64%)
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:429748
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148 10/66 (15%)
BTB_POZ 176..303 CDD:453885 97/126 (77%)
Ion_trans 306..570 CDD:459842 176/274 (64%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385 651..653
Blue background indicates that the domain is not in the aligned region.

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