Protein Alignment Sh and KCNA3

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_002223.3
• Gene: KCNA3 / 3738
• HGNCID: 6221
• Length: 575
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 327/500 - (65%)
• Similarity: 383/500 - (76%)
• Gaps: 43/500 - (8%)

  Fly    52 LQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIP------HDHDFC-ERVVINVSGLRFE 109
            |:....||.|:.|       :||.|   |||...:||:|      .:.|.| ||||||:||||||
Human    62 LEPEVADGGGAPP-------QGGCG---GGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFE 116

  Fly   110 TQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFS 174
            |||:||.|||:||||||.||:||||||||||||||:||||||||||||||||:|||||||:|:||
Human   117 TQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFS 181

  Fly   175 EEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILL 239
            |||:||:||::|:.||||||||::|||||||..:.||:|||||||||||..||.:||:||.|||:
Human   182 EEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILI 246

  Fly   240 SIVIFCLETLPEFKHYKVFNTTT---------NGTKIEEDEVPDITDPFFLIETLCIIWFTFELT 295
            |||||||||||||:..|.:..:|         |.|..........:||||::||||||||:|||.
Human   247 SIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELL 311

  Fly   296 VRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAI 360
            |||.|||:|..|.|::||:|||:|||||||||.|.:||.:.              :..|||||||
Human   312 VRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQG--------------NGQQAMSLAI 362

  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSF 425
            ||||||||||||||||||||||||||:||||||||||||||||||||:|||||||||||....|.
Human   363 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSG 427

  Fly   426 FKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 490
            |.|||||||||||||||||||||.||.:.|||||||||||||||||||||||||||||||||||:
Human   428 FSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE 492

  Fly   491 QEEMQSQNFNHVTSCPYLPGTLGQHMK-KSSLSESSSDMMDLDDG 534
            .|| ||| :.||.||.:|..:..:..| :|:.:.|.|:.|.:::|
Human   493 GEE-QSQ-YMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEG 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	102/125 (82%)
		Ion_trans	226..488	CDD:459842	188/270 (70%)
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		BTB_POZ	104..230	CDD:453885	102/125 (82%)
		Ion_trans	233..490	CDD:459842	188/270 (70%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	444..449		4/4 (100%)
		Interaction with KCNE4. /evidence=ECO:0000250|UniProtKB:P15384	482..575		25/55 (45%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15384	573..575