DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sh and KCNA3

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_002223.3 Gene:KCNA3 / 3738 HGNCID:6221 Length:575 Species:Homo sapiens


Alignment Length:500 Identity:326/500 - (65%)
Similarity:383/500 - (76%) Gaps:43/500 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIP------HDHDFC-ERVVINVSGLRFE 109
            |:....||.|:.|       :||.|   |||...:||:|      .:.|.| ||||||:||||||
Human    62 LEPEVADGGGAPP-------QGGCG---GGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFE 116

  Fly   110 TQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFS 174
            |||:||.|||:||||||.||:||||||||||||||:||||||||||||||||:|||||||:|:||
Human   117 TQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFS 181

  Fly   175 EEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILL 239
            |||:||:||::|:.||||||||::|||||||..:.||:|||||||||||..||.:||:||.|||:
Human   182 EEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILI 246

  Fly   240 SIVIFCLETLPEFKHYKVFNTTT---------NGTKIEEDEVPDITDPFFLIETLCIIWFTFELT 295
            |||||||||||||:..|.:..:|         |.|..........:||||::||||||||:|||.
Human   247 SIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELL 311

  Fly   296 VRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAI 360
            |||.|||:|..|.|::||:|||:|||||||||.|.:||.:.              :..|||||||
Human   312 VRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQG--------------NGQQAMSLAI 362

  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSF 425
            ||||||||||||||||||||||||||:||||||||||||||||||||:|||||||||||...:|.
Human   363 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSG 427

  Fly   426 FKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 490
            |.||||.||||||||||||||||.||.:.|||||||||||||||||||||||||||||||||||:
Human   428 FSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE 492

  Fly   491 QEEMQSQNFNHVTSCPYLPGTLGQHMK-KSSLSESSSDMMDLDDG 534
            .|| ||| :.||.||.:|..:..:..| :|:.:.|.|:.|.:::|
Human   493 GEE-QSQ-YMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEG 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 73/87 (84%)
BTB 99..182 CDD:197585 71/82 (87%)
Ion_trans 274..488 CDD:278921 161/213 (76%)
Ion_trans_2 403..479 CDD:285168 63/75 (84%)
KCNA3NP_002223.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
BTB 106..200 CDD:197585 77/93 (83%)
BTB_2 106..197 CDD:280393 74/90 (82%)
Ion_trans 290..490 CDD:278921 161/213 (76%)
Ion_trans_2 404..481 CDD:285168 64/76 (84%)
Selectivity filter. /evidence=ECO:0000250 444..449 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 573..575
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 362 1.000 Domainoid score I953
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H128570
Inparanoid 1 1.050 620 1.000 Inparanoid score I885
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48093
OrthoDB 1 1.010 - - D307298at33208
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 1 1.000 - - otm42203
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3654
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.910

Return to query results.
Submit another query.