Protein Alignment Sh and Kcng2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001100842.1
• Gene: Kcng2 / 307234
• RGDID: 1309521
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 527
• Identity: 146/527 - (27%)
• Similarity: 235/527 - (44%)
• Gaps: 97/527 - (18%)

  Fly    57 LDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDT 121
            |.|:..:|.........|...|.|...:|             |:|||.|.|.......|.:.|..
  Rat     4 LPGHPEVPGAEPGSAVRGGRGGRGARARH-------------VIINVGGCRVRLAWAALARCPLA 55

  Fly   122 LLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAILYYYQSG--GRLRRPVNVPLD 171
            .|    .|||.             :|..|:|:|||||..:|.||:...::|  ..||.|..:
  Rat    56 RL----ERLRACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCAL--- 113

  Fly   172 VFSEEIKFYELGDQAINKF-------REDEGFIKEEERPLPD-----------------NEKQRK 212
            .|.:|:.::.:.:..:.:.       ||:|.   .|.|..|.                 ...:|:
  Rat   114 AFRDELAYWGIDEARLERCCLRRLRRREEEA---AEARATPPARGPQTSPGRALGSGRLERGRRR 175

  Fly   213 VWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITD 277
            :..:.|.|.|..|.::.|.:||..:.::.|..||.|:|:.:           .:.|..|......
  Rat   176 LRDVVENPHSGLAGKLFAYVSVAFVAVTAVGLCLSTMPDVR-----------AEEERGECSTKCR 229

  Fly   278 PFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPK 342
            ..|::||:|:.||:||..:|.|...:|..|.|..:.:|||:||:|::::|...:|
  Rat   230 NLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAIIDILAILPFYVSLLAGLA---------- 284

  Fly   343 APVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGV 407
              ..|......:...| :||::|.:||..:.:|:|||.||:.||.|::...||.|||:.||.:.:
  Rat   285 --AGPTGSKMLERAGL-VLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAM 346

  Fly   408 VLFSSAVYFA--EAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTI 470
            .||:..|:.|  |.|:... |.|:|.::||||::|||||||||.|..:.|::|.....::|:|.:
  Rat   347 ALFAPLVHLAERELGAHRD-FSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLM 410

  Fly   471 ALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYL--PGTLGQHMKKSSLSESSSDMMDLDD 533
            |.||..|...|:..|      .|::.|.....:..|.|  ..|.....:.:|.:|.||...:...
  Rat   411 AFPVTSIFHTFSRSY------SELKEQQQRAASPEPVLREDSTRDDSTRSASATEDSSQDPETAG 469

  Fly   534 GVESTPG 540
            ...|.||
  Rat   470 AAGSLPG 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	38/164 (23%)
		Ion_trans	226..488	CDD:459842	87/263 (33%)
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		4/20 (20%)
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	29/100 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..167		3/25 (12%)
		Ion_trans	190..429	CDD:459842	88/269 (33%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..480		11/48 (23%)