DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and Kcng2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001100842.1	Gene:	Kcng2 / 307234	RGDID:	1309521	Length:	480	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	147/529 - (27%)
Similarity:	234/529 - (44%)	Gaps:	101/529 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDT 121
            |.|:..:|.........|...|.|...:|             |:|||.|.|.......|.:.|..
  Rat     4 LPGHPEVPGAEPGSAVRGGRGGRGARARH-------------VIINVGGCRVRLAWAALARCPLA 55

  Fly   122 LLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAILYYYQSG--GRLRRPVNVPLD 171
            .|    .|||.             :|..|:|:|||||..:|.||:...::|  ..||.|..:
  Rat    56 RL----ERLRACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCAL--- 113

  Fly   172 VFSEEIKFYELGDQAINKF-------REDEGFIKEEERPLPD-----------------NEKQRK 212
            .|.:|:.::.:.:..:.:.       ||:|.   .|.|..|.                 ...:|:
  Rat   114 AFRDELAYWGIDEARLERCCLRRLRRREEEA---AEARATPPARGPQTSPGRALGSGRLERGRRR 175

  Fly   213 VWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITD 277
            :..:.|.|.|..|.::.|.:||..:.::.|..||.|:|:.:           .:.|..|......
  Rat   176 LRDVVENPHSGLAGKLFAYVSVAFVAVTAVGLCLSTMPDVR-----------AEEERGECSTKCR 229

  Fly   278 PFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPK 342
            ..|::||:|:.||:||..:|.|...:|..|.|..:.:|||:||:|::::|...:|
  Rat   230 NLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAIIDILAILPFYVSLLAGLA---------- 284

  Fly   343 APVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGV 407
              ..|......:...| :||::|.:||..:.:|:|||.||:.||.|::...||.|||:.||.:.:
  Rat   285 --AGPTGSKMLERAGL-VLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAM 346

  Fly   408 VLFSSAVYFAE----AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVL 468
            .||:..|:.||    |..|   |.|:|..:||||::|||||||||.|..:.|::|.....::|:|
  Rat   347 ALFAPLVHLAERELGAHRD---FSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGIL 408

  Fly   469 TIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYL--PGTLGQHMKKSSLSESSSDMMDL 531
            .:|.||..|...|:..|      .|::.|.....:..|.|  ..|.....:.:|.:|.||...:.
  Rat   409 LMAFPVTSIFHTFSRSY------SELKEQQQRAASPEPVLREDSTRDDSTRSASATEDSSQDPET 467

  Fly   532 DDGVESTPG 540
            .....|.||
  Rat   468 AGAAGSLPG 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	29/102 (28%)
		BTB	99..182	CDD:197585	29/97 (30%)
		Ion_trans	274..488	CDD:278921	78/217 (36%)
		Ion_trans_2	403..479	CDD:285168	33/79 (42%)
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		4/20 (20%)
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	29/100 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..167		3/25 (12%)
		Ion_trans	190..429	CDD:395416	89/271 (33%)
		Selectivity filter. /evidence=ECO:0000250	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..480		11/48 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910