Protein Alignment Sh and Kcnf1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001162575.1
• Gene: Kcnf1 / 298908
• RGDID: 631414
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 518
• Identity: 156/518 - (30%)
• Similarity: 250/518 - (48%)
• Gaps: 122/518 - (23%)

  Fly    62 SLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDP 126
            |||:..|||...|                   |..| :|:||.|:|.......|:|:|:|.|.:.
  Rat    20 SLPEPGSQDSVAG-------------------DDIE-IVVNVGGVRQVLYGDLLSQYPETRLAEL 64

  Fly   127 ARRLR--Y---------FDPLRNEYFFDRSRPSFDAIL--YYYQSGGRLRRPVNVPLDVFSEEIK 178
            ...|.  |         :||.:.|::|||...:|..::  ||:   |.:.....:....|..|:.
  Rat    65 INCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYF---GEVHMKKGICPICFKNEMD 126

  Fly   179 FYELGDQAINKFRED--EGFIKEEERPLPDNEK---------------------QRKVWLLFEYP 220
            |:::.    .||.:|  :..:.|:...|.:..:                     |:.||...|.|
  Rat   127 FWKVD----LKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKP 187

  Fly   221 ESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETL 285
            |||..|||||::|..:||:|.|:.|:.|:||.:     ...:.|.::|...:.:       :||.
  Rat   188 ESSCPARVVAVLSFLLILVSSVVMCMGTIPELQ-----VVDSEGNRVEHPTLEN-------VETA 240

  Fly   286 CIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFI--TLATVVAEEEDTLNLPKAPVSPQ 348
            ||.|||.|..:|..:.||||:|....||::|::||:|:::  ||..:.|...:..|:.:|
  Rat   241 CIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQA----- 300

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSA 413
                        ::.:|::|:.|||||:|||.|||.|...||.|.:|||||:.:|.:|:.:||:.
  Rat   301 ------------VQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSAL 353

  Fly   414 VYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIV 478
            .|..|.....:.|||||.:||||::|||||||||:.|....||:..::..:.||:.||||:..|:
  Rat   354 GYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPII 418

  Fly   479 SNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLD-DGVESTPG 540
            :||..:|:::...|                  |..:|         ..::|:|: ...||.||
  Rat   419 NNFVRYYNKQRVLE------------------TAAKH---------ELELMELNSSSAESKPG 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	37/161 (23%)
		Ion_trans	226..488	CDD:459842	100/263 (38%)
Kcnf1	NP_001162575.1	BTB_POZ_Kv5_KCNF1	35..150	CDD:349690	30/122 (25%)
		Ion_trans	193..429	CDD:459842	100/264 (38%)