DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and Kcnf1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001162575.1	Gene:	Kcnf1 / 298908	RGDID:	631414	Length:	505	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	156/518 - (30%)
Similarity:	249/518 - (48%)	Gaps:	122/518 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDP 126
            |||:..|||...|                   |..| :|:||.|:|.......|:|:|:|.|.:.
  Rat    20 SLPEPGSQDSVAG-------------------DDIE-IVVNVGGVRQVLYGDLLSQYPETRLAEL 64

  Fly   127 ARRLR--Y---------FDPLRNEYFFDRSRPSFDAIL--YYYQSGGRLRRPVNVPLDVFSEEIK 178
            ...|.  |         :||.:.|::|||...:|..::  ||:   |.:.....:....|..|:.
  Rat    65 INCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYF---GEVHMKKGICPICFKNEMD 126

  Fly   179 FYELGDQAINKFRED--EGFIKEEERPLPDNEK---------------------QRKVWLLFEYP 220
            |:::.    .||.:|  :..:.|:...|.:..:                     |:.||...|.|
  Rat   127 FWKVD----LKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKP 187

  Fly   221 ESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETL 285
            |||..|||||::|..:||:|.|:.|:.|:||.:     ...:.|.::|...:.:       :||.
  Rat   188 ESSCPARVVAVLSFLLILVSSVVMCMGTIPELQ-----VVDSEGNRVEHPTLEN-------VETA 240

  Fly   286 CIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFI--TLATVVAEEEDTLNLPKAPVSPQ 348
            ||.|||.|..:|..:.||||:|....||::|::||:|:::  ||..:.|...:..|:.:|
  Rat   241 CIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQA----- 300

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSA 413
                        ::.:|::|:.|||||:|||.|||.|...||.|.:|||||:.:|.:|:.:||:.
  Rat   301 ------------VQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSAL 353

  Fly   414 VYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIV 478
            .|..|.....:.|||||..||||::|||||||||:.|....||:..::..:.||:.||||:..|:
  Rat   354 GYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPII 418

  Fly   479 SNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLD-DGVESTPG 540
            :||..:|:::...|                  |..:|         ..::|:|: ...||.||
  Rat   419 NNFVRYYNKQRVLE------------------TAAKH---------ELELMELNSSSAESKPG 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	25/100 (25%)
		BTB	99..182	CDD:197585	25/95 (26%)
		Ion_trans	274..488	CDD:278921	84/215 (39%)
		Ion_trans_2	403..479	CDD:285168	34/75 (45%)
Kcnf1	NP_001162575.1	BTB	37..147	CDD:197585	29/116 (25%)
		BTB	37..138	CDD:295341	27/107 (25%)
		Ion_trans	234..429	CDD:278921	84/218 (39%)
		Ion_trans_2	343..412	CDD:285168	30/68 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810