DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and Kcng1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001100015.1	Gene:	Kcng1 / 296395	RGDID:	631416	Length:	514	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	154/521 - (29%)
Similarity:	239/521 - (45%)	Gaps:	99/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QRNSLDG--YGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDH----DFCERVVINVSGLRFETQ 111
            ||.::.|  |....:|..||:                  .|..    |...:::|||.|:::...
  Rat    31 QRQAIKGVFYRRAQRLGPQDD------------------LHQSISLGDRRRQIIINVGGIKYSLP 77

  Fly   112 LRTLNQFPDTLLGDPARRLRY---------FDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVN 167
            ..||::||.|.||.......:         :|...||:||||:..:|..||.:.:: |:||....
  Rat    78 WTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRA-GKLRLLRE 141

  Fly   168 VPLDVFSEEIKFYELGD------------QAINKF-----REDEGFIKEEERPLPDNEKQ----- 210
            :....|.||:.::.:.:            |.|.:|     ||||    ||.....|.|.:
  Rat   142 MCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREDE----EEALDSEDQESEGPSTS 202

  Fly   211 --------RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKI 267
                    |::..:.|.|.|....:|.|.:||..:.::.|...:.|||..:..:
  Rat   203 EGRLSRCMRRLRDMVEKPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEE----------- 256

  Fly   268 EEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVA 332
            |:.:...:....|::|::|:.||:.|..:||:..|:|..|.|..:.:||::||:||::||  :|.
  Rat   257 EQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTL--LVD 319

  Fly   333 EEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELG 397
            ....:...|....|..||..      .:|||:|.:|:..:.:|:|||.|||.||.|.:...||.|
  Rat   320 GAASSRRKPSTGNSYLDKVG------LVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFG 378

  Fly   398 LLIFFLFIGVVLFSSAVYFAE-AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSL 461
            ||:.||.:.:.||:..:|..| ..:||..|.|||..:||||:||||||||||.|....|::|...
  Rat   379 LLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALS 443

  Fly   462 CAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSS 526
            ..::|:|.:|.||..|...|:..|     .|..|.|....:....||..|      ||.||..|.
  Rat   444 SILSGILLMAFPVTSIFHTFSRSY-----LELKQEQERVLIRRAQYLIKT------KSQLSGMSQ 497

  Fly   527 D 527
            |
  Rat   498 D 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	28/108 (26%)
		BTB	99..182	CDD:197585	27/91 (30%)
		Ion_trans	274..488	CDD:278921	82/214 (38%)
		Ion_trans_2	403..479	CDD:285168	34/76 (45%)
Kcng1	NP_001100015.1	BTB	65..169	CDD:197585	27/104 (26%)
		BTB_2	65..164	CDD:280393	27/99 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..205		8/27 (30%)
		Ion_trans	256..471	CDD:278921	84/238 (35%)
		Ion_trans_2	383..465	CDD:285168	36/81 (44%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	424..429		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910