Protein Alignment Sh and Kcng1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001100015.1
• Gene: Kcng1 / 296395
• RGDID: 631416
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 152/521 - (29%)
• Similarity: 239/521 - (45%)
• Gaps: 99/521 - (19%)

  Fly    53 QRNSLDG--YGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDH----DFCERVVINVSGLRFETQ 111
            ||.::.|  |....:|..||:                  .|..    |...:::|||.|:::...
  Rat    31 QRQAIKGVFYRRAQRLGPQDD------------------LHQSISLGDRRRQIIINVGGIKYSLP 77

  Fly   112 LRTLNQFPDTLLGDPARRLRY---------FDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVN 167
            ..||::||.|.||.......:         :|...||:||||:..:|..||.:.:: |:||....
  Rat    78 WTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRA-GKLRLLRE 141

  Fly   168 VPLDVFSEEIKFYELGD------------QAINKF-----REDEGFIKEEERPLPDNEKQ----- 210
            :....|.||:.::.:.:            |.|.:|     ||||    ||.....|.|.:
  Rat   142 MCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREDE----EEALDSEDQESEGPSTS 202

  Fly   211 --------RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKI 267
                    |::..:.|.|.|....:|.|.:||..:.::.|...:.|||..:..:
  Rat   203 EGRLSRCMRRLRDMVEKPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEE----------- 256

  Fly   268 EEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVA 332
            |:.:...:....|::|::|:.||:.|..:||:..|:|..|.|..:.:||::||:||::||  :|.
  Rat   257 EQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTL--LVD 319

  Fly   333 EEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELG 397
            ....:...|....|..||..      .:|||:|.:|:..:.:|:|||.|||.||.|.:...||.|
  Rat   320 GAASSRRKPSTGNSYLDKVG------LVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFG 378

  Fly   398 LLIFFLFIGVVLFSSAVYFAE-AGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSL 461
            ||:.||.:.:.||:..:|..| ..:::..|.|||..:||||:||||||||||.|....|::|...
  Rat   379 LLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALS 443

  Fly   462 CAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSS 526
            ..::|:|.:|.||..|...|:..|     .|..|.|....:....||..|      ||.||..|.
  Rat   444 SILSGILLMAFPVTSIFHTFSRSY-----LELKQEQERVLIRRAQYLIKT------KSQLSGMSQ 497

  Fly   527 D 527
            |
  Rat   498 D 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	41/164 (25%)
		Ion_trans	226..488	CDD:459842	89/262 (34%)
Kcng1	NP_001100015.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	29/113 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..205		8/27 (30%)
		Ion_trans	227..471	CDD:459842	90/267 (34%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)