Protein Alignment Sh and Kcnc2

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001346681.1
• Gene: Kcnc2 / 268345
• MGIID: 96668
• Length: 642
• Species: Mus musculus
• Alignment Length: 580
• Identity: 193/580 - (33%)
• Similarity: 273/580 - (47%)
• Gaps: 164/580 - (28%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLL----------------GD----------PARRLRYFDP 135
            |||::||.|.|.||...||...|.|.|                ||          |..|.....|
Mouse     8 ERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQGDCLTAAGDKLQPLPPPLSPPPRPPPLSP 72

  Fly   136 LRN-----------------------------EYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLD 171
            :.:                             |:||||....|..:|.||:: |:|..|.:|...
Mouse    73 VPSGCFEGGAGNCSSHGGNGGNGGSDHPGGGREFFFDRHPGVFAYVLNYYRT-GKLHCPADVCGP 136

  Fly   172 VFSEEIKFYEL------------------GDQAINKFR----------EDEGFIK-----EEERP 203
            :|.||:.|:.:                  .::|::.|.          :||....     |:...
Mouse   137 LFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAG 201

  Fly   204 L--PDNEK------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNT 260
            |  ||.:.      |.::|.|||.|.||:|||.:|..|:|.||:||..|||||...|...|  |.
Mouse   202 LGGPDGKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVK--NK 264

  Fly   261 T---TNGT------KIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVID 316
            |   .|||      :||.|  |.:|    .:|.:|::|||||..||.:..||||.|.::::|:||
Mouse   265 TEPVINGTSPVLQYEIETD--PALT----YVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIID 323

  Fly   317 IIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHSK 380
            .:||:|:::                  .|.....||..|.. |..|||:|.||:.|||||:||..
Mouse   324 FVAILPFYL------------------EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV 370

  Fly   381 GLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSDSSFFKSIPDGFWWA 436
            ||::||.||:||..|..|||.||.:||::|::.:|:||         :.|:.:.||:||.|||||
Mouse   371 GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWA 435

  Fly   437 VVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNH 501
            ||||||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....::::..:...|
Mouse   436 VVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKH 500

  Fly   502 VTSCPYLPG-------------------TLGQHMKKSSLSESSSDMMDLDDGVESTPGLT 542
            :...|....                   .||   |::.|.|.:..::..||...|.|.|:
Mouse   501 IPPAPLASSPTFCKTELNMACNSTQSDTCLG---KENRLLEHNRSVLSGDDSTGSEPPLS 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	34/160 (21%)
		BTB	99..182	CDD:197585	34/137 (25%)
		Ion_trans	274..488	CDD:278921	103/223 (46%)
		Ion_trans_2	403..479	CDD:285168	47/84 (56%)
Kcnc2	NP_001346681.1	BTB_KCNC2_4	7..170	CDD:349722	36/162 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..98		5/52 (10%)
		Ion_trans	232..488	CDD:395416	128/281 (46%)
		Selectivity filter. /evidence=ECO:0000250	441..446		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..576		5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810