DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and KCNG2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_016881193.1	Gene:	KCNG2 / 26251	HGNCID:	6249	Length:	509	Species:	Homo sapiens

Alignment Length:	506	Identity:	139/506 - (27%)
Similarity:	231/506 - (45%)	Gaps:	108/506 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRY---------- 132
            |.|||.:           ...|:|||.|.|.......|.:.|...|    .|||.
Human    52 GGGGGTR-----------ARHVIINVGGCRVRLAWAALARCPLARL----ERLRACRGHDDLLRV 101

  Fly   133 ---FDPLRNEYFFDRSRPSFDAILYYYQSG--GRLRRPVNVPLDVFSEEIKFYELGDQAINKF-- 190
               :|..|:|:|||||..:|.||:...::|  ..||.|..:   .|.:|:.::.:.:..:.:.
Human   102 CDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCAL---AFRDELAYWGIDEARLERCCL 163

  Fly   191 -----REDEGFIKEEERPLPD------------------NEKQRKVWLLFEYPESSQAARVVAII 232
                 ||:|.   .|.|..|.                  ...:|::..:.:.|.|..|.::.|.:
Human   164 RRLRRREEEA---AEARAGPTERGAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKLFACV 225

  Fly   233 SVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVR 297
            ||..:.::.|..||.|:|:.:           .:.|..|........|::||:|:.||:||..:|
Human   226 SVSFVAVTAVGLCLSTMPDIR-----------AEEERGECSPKCRSLFVLETVCVAWFSFEFLLR 279

  Fly   298 FLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLA--I 360
            .|...:|..|.|..:|:|||:|::|::::|         .|.|...|      ...:.:..|  :
Human   280 SLQAESKCAFLRAPLNIIDILALLPFYVSL---------LLGLAAGP------GGTKLLERAGLV 329

  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE----AGS 421
            ||::|.:||..:.:|:|||.||:.||.|::...||.|||:.||.:.:.||:..|:.||    |..
Human   330 LRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARR 394

  Fly   422 DSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 486
            |   |.|:|..:||||::|||||||||.|..:.|::|.....::|:|.:|.||..|...|:..|.
Human   395 D---FSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYS 456

  Fly   487 RETDQEE--------MQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMM 529
            ...:|::        :|..:.:..|:..    ...|....:.|::.|:|.:
Human   457 ELKEQQQRAASPEPALQEDSTHSATATE----DSSQGPDSAGLADDSADAL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	29/102 (28%)
		BTB	99..182	CDD:197585	29/97 (30%)
		Ion_trans	274..488	CDD:278921	79/219 (36%)
		Ion_trans_2	403..479	CDD:285168	33/79 (42%)
KCNG2	XP_016881193.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810