Protein Alignment Sh and Kcnb1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_037318.2
• Gene: Kcnb1 / 25736
• RGDID: 2954
• Length: 857
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 205/624 - (32%)
• Similarity: 310/624 - (49%)
• Gaps: 125/624 - (20%)

  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPL----------RNEYFFDRSRPSFDAI 152
            ||.:||.||..|...|||::.|.|.|| ..|.....|.|          .|||||||...:|.:|
  Rat    32 RVRLNVGGLAHEVLWRTLDRLPRTRLG-KLRDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEI----------------KFYELGDQAINKFREDEGFIKEEE 201
            |.:|:: |||.....:....||:|:                ::::..:|...:.:.:...::|.|
  Rat    96 LNFYRT-GRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLRERE 159

  Fly   202 RPLPDN----EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTT 262
            ....||    ||::|:|.|.|.|.||.||:::||||:..|:||.:...|.||||.:....|..:|
  Rat   160 GEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST 224

  Fly   263 NGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITL 327
            :..::..            :|.:||.|||.|..:|||:.|.|..|.:..:|.||::||:||::|:
  Rat   225 DNPQLAH------------VEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTI 277

  Fly   328 ATVVAEEEDTLNLPKAPVSPQDKSSNQAMSL-AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKA 391
            .                ::..:||..|..:: .::::.|::|:.||.||:|||.|||.||.||:.
  Rat   278 F----------------LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRR 326

  Fly   392 SMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGK 456
            |..||||||.||.:|:::|||.|:|||...:::.|||||.:||||.:|||||||||:.|..:.||
  Rat   327 SYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGK 391

  Fly   457 IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE---------EMQSQNFNHVTSCPYLPGTL 512
            |||.||.|||||.||||:|:||:||:.||..:..||         |...:|.:.|:
  Rat   392 IVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS--------- 447

  Fly   513 GQHMKKSSLSESSSDMMDL-----------DDGVES---TP--------GLTETHPGRSAVAPFL 555
               |........|.:|||:           .|.|:.   :|        .|:||...:|    |.
  Rat   448 ---MNMKDAFARSIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKS----FE 505

  Fly   556 GAQQQQQQPVASSLSMSIDKQLQH-PLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQ--QQLQQ 617
            ..:|...:...||.|.      || .:|||  ..:|.:..:.|.|.....|:...|::  ::|:.
  Rat   506 TKEQGSPEKARSSSSP------QHLNVQQL--EDMYSKMAKTQSQPILNTKEMAPQSKPPEELEM 562

  Fly   618 QQSHTINASAAAATSGSGSSGLTMRHNNAL--AVSIETD 654
            ....:..|...|.|.|.    :.||..:::  .:|..||
  Rat   563 SSMPSPVAPLPARTEGV----IDMRSMSSIDSFISCATD 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	46/154 (30%)
		Ion_trans	226..488	CDD:459842	114/262 (44%)
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	34/110 (31%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	59..75		3/15 (20%)
		Ion_trans	188..424	CDD:459842	114/263 (43%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	448..481		7/32 (22%)
		Kv2channel	467..678	CDD:397541	32/147 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..524		13/57 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..569		5/28 (18%)
		FFAT. /evidence=ECO:0000250|UniProtKB:Q14721	590..596		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..658
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..802
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..857