DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sh and Kcnb1

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_037318.2 Gene:Kcnb1 / 25736 RGDID:2954 Length:857 Species:Rattus norvegicus


Alignment Length:624 Identity:206/624 - (33%)
Similarity:308/624 - (49%) Gaps:125/624 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPL----------RNEYFFDRSRPSFDAI 152
            ||.:||.||..|...|||::.|.|.|| ..|.....|.|          .|||||||...:|.:|
  Rat    32 RVRLNVGGLAHEVLWRTLDRLPRTRLG-KLRDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEI----------------KFYELGDQAINKFREDEGFIKEEE 201
            |.:|:: |||.....:....||:|:                ::::..:|...:.:.:...::|.|
  Rat    96 LNFYRT-GRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLRERE 159

  Fly   202 RPLPDN----EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTT 262
            ....||    ||::|:|.|.|.|.||.||:::||||:..|:||.:...|.||||.:....|..:|
  Rat   160 GEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQST 224

  Fly   263 NGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITL 327
            :..::..            :|.:||.|||.|..:|||:.|.|..|.:..:|.||::||:||::|:
  Rat   225 DNPQLAH------------VEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTI 277

  Fly   328 ATVVAEEEDTLNLPKAPVSPQDKSSNQAMSL-AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKA 391
            .                ::..:||..|..:: .::::.|::|:.||.||:|||.|||.||.||:.
  Rat   278 F----------------LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRR 326

  Fly   392 SMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGK 456
            |..||||||.||.:|:::|||.|:|||...|.:.|||||..||||.:|||||||||:.|..:.||
  Rat   327 SYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGK 391

  Fly   457 IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE---------EMQSQNFNHVTSCPYLPGTL 512
            |||.||.|||||.||||:|:||:||:.||..:..||         |...:|.:.|:         
  Rat   392 IVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS--------- 447

  Fly   513 GQHMKKSSLSESSSDMMDL-----------DDGVES---TP--------GLTETHPGRSAVAPFL 555
               |........|.:|||:           .|.|:.   :|        .|:||...:|    |.
  Rat   448 ---MNMKDAFARSIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKS----FE 505

  Fly   556 GAQQQQQQPVASSLSMSIDKQLQH-PLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQ--QQLQQ 617
            ..:|...:...||.|.      || .:|||  ..:|.:..:.|.|.....|:...|::  ::|:.
  Rat   506 TKEQGSPEKARSSSSP------QHLNVQQL--EDMYSKMAKTQSQPILNTKEMAPQSKPPEELEM 562

  Fly   618 QQSHTINASAAAATSGSGSSGLTMRHNNAL--AVSIETD 654
            ....:..|...|.|.|.    :.||..:::  .:|..||
  Rat   563 SSMPSPVAPLPARTEGV----IDMRSMSSIDSFISCATD 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 34/113 (30%)
BTB 99..182 CDD:197585 33/108 (31%)
Ion_trans 274..488 CDD:278921 100/214 (47%)
Ion_trans_2 403..479 CDD:285168 47/75 (63%)
Kcnb1NP_037318.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
BTB_POZ_KCNB2 15..141 CDD:349719 34/110 (31%)
Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160 59..75 3/15 (20%)
Ion_trans 188..424 CDD:395416 115/263 (44%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 4/4 (100%)
Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160 448..481 7/32 (22%)
Kv2channel 467..678 CDD:397541 32/147 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..524 13/57 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..569 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..857
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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