DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcna5

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_037104.1	Gene:	Kcna5 / 25470	RGDID:	2953	Length:	602	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	302/458 - (65%)
Similarity:	350/458 - (76%)	Gaps:	45/458 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KLSSQDEEGGAGHGFG-----GGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLG 124
            :||::||||....|.|     ..||....:.|     :||:||:|||||||||.||.|||:||||
  Rat    79 RLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHH-----QRVLINISGLRFETQLGTLAQFPNTLLG 138

  Fly   125 DPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINK 189
            |||:||.|||||||||||||:|||||.|||||||||||||||||.||||::||:||:|||:|:.:
  Rat   139 DPAKRLHYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMER 203

  Fly   190 FREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKH 254
            ||||||||||||:|||.||.||:|||:|||||||.:||.:||:||.|||:||:.|||||||||:.
  Rat   204 FREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRD 268

  Fly   255 YK----------------------VFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVR 297
            .:                      |....::|..:.......:.||||::||.|:|||||||.||
  Rat   269 ERELLRHPPVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVR 333

  Fly   298 FLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSN--QAMSLAI 360
            |.|||:|..|.|::||:||::||.||||||.|.:||::           |.....|  |||||||
  Rat   334 FFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQ-----------PGGGGQNGQQAMSLAI 387

  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSF 425
            ||||||||||||||||||||||||||:||:|||||||||||||||||:|||||||||||.:..|.
  Rat   388 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHGSH 452

  Fly   426 FKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 490
            |.||||.||||||||||||||||||:.|.||||||||||||||||||||||||||||||||||||
  Rat   453 FSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 517

  Fly   491 QEE 493
            .||
  Rat   518 HEE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	72/87 (83%)
		BTB	99..182	CDD:197585	69/82 (84%)
		Ion_trans	274..488	CDD:278921	160/215 (74%)
		Ion_trans_2	403..479	CDD:285168	64/75 (85%)
Kcna5	NP_037104.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..107		10/27 (37%)
		BTB	113..207	CDD:197585	75/93 (81%)
		BTB_2	113..204	CDD:280393	73/90 (81%)
		Ion_trans	305..515	CDD:278921	160/220 (73%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	407..420		10/12 (83%)
		Ion_trans_2	429..506	CDD:285168	65/76 (86%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	469..474		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..543
		PDZ-binding	600..602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		otm46354
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790