DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sh and Kcna4

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_037103.2 Gene:Kcna4 / 25469 RGDID:2952 Length:654 Species:Rattus norvegicus


Alignment Length:579 Identity:322/579 - (55%)
Similarity:408/579 - (70%) Gaps:67/579 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GEDRQHRKKQQQQQQHQ---------------------KEQLEQKEEQKKIAERKLQLREQQLQR 54
            |..|:.|::.::::.|.                     :|..|::|::::..|.:.:.|....:.
  Rat    81 GSRRRRRQRTEKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEE 145

  Fly    55 NSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFP 119
            :..||. |...|..||:.||.|         :..:.:. |.||||||||||||||||::||.|||
  Rat   146 DHGDGC-SYTDLLPQDDGGGGG---------YSSVRYS-DCCERVVINVSGLRFETQMKTLAQFP 199

  Fly   120 DTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGD 184
            :||||||.:|.:|||||||||||||:|||||||||||||||||:||||||.|:|:||:|||:||:
  Rat   200 ETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE 264

  Fly   185 QAINKFREDEGFIKEEE-RPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET 248
            :|:.||||||||::||| |.||:||.::::||||||||||..||.:||:||.|||:|||||||||
  Rat   265 EALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLET 329

  Fly   249 LPEFK-------------HYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLA 300
            ||||:             |.::.| .|:...:|........||||::||:||:||:||..||..|
  Rat   330 LPEFRDDRDLIMALSAGGHSRLLN-DTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA 393

  Fly   301 CPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIR 365
            ||::..|.:::||:|||::|:||||||.|.:|:::...|          ....||||.||||:||
  Rat   394 CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGN----------GQQQQAMSFAILRIIR 448

  Fly   366 LVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIP 430
            |||||||||||||||||||||.||:|||||||||||||||||:|||||||||||....:.|:|||
  Rat   449 LVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIP 513

  Fly   431 DAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQ 495
            ||||||||||||||||||.|:.|.|||||||||||||||||||||||||||||||||||:.|| |
  Rat   514 DAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE-Q 577

  Fly   496 SQNFNHVTSCPYLPGTLGQHMKKSSLSESS-----SDMMDLDDGV-ESTPGLTETHPGR 548
            :|...:..||||||..|   :||...|.||     |:.:::::|| ||..|..|...|:
  Rat   578 TQLTQNAVSCPYLPSNL---LKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGK 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 97/126 (77%)
Ion_trans 226..488 CDD:459842 176/274 (64%)
Kcna4NP_037103.2 K_channel_TID 1..>37 CDD:429748
BTB_POZ 177..304 CDD:453885 97/126 (77%)
Ion_trans 307..571 CDD:459842 176/274 (64%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 463..476 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 525..530 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..654 1/4 (25%)
PDZ-binding. /evidence=ECO:0000269|PubMed:7477295 652..654
Blue background indicates that the domain is not in the aligned region.

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