DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna2

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_037102.1 Gene:Kcna2 / 25468 RGDID:2950 Length:499 Species:Rattus norvegicus


Alignment Length:467 Identity:320/467 - (68%)
Similarity:373/467 - (79%) Gaps:24/467 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 GGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRS 145
            |.||.......||:.|||||||:|||||||||:||.|||:||||||.:|:||||||||||||||:
  Rat    17 GHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRN 81

  Fly   146 RPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQ 210
            ||||||||||||||||||||||||||:|||||:|||||::|:..||||||:|||||||||:||.|
  Rat    82 RPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQ 146

  Fly   211 RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYK--------VFNTTTNGTKI 267
            |:|||||||||||..||::||:||.|||:|||.|||||||.|:...        .|:|.:|.| |
  Rat   147 RQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNST-I 210

  Fly   268 EEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVA 332
            ...:....|||||::||||||||:||..|||.|||:|..|..::||:|||:|||||||||.|.:|
  Rat   211 GYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELA 275

  Fly   333 EEEDTLNLPKAPVSPQD-KSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMREL 396
            |:            |:| :...|||||||||||||||||||||||||||||||||:|||||||||
  Rat   276 EK------------PEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMREL 328

  Fly   397 GLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSL 461
            |||||||||||:|||||||||||...:|.|.|||||||||||:|||||||||.|..:.|||||||
  Rat   329 GLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSL 393

  Fly   462 CAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSS 526
            ||||||||||||||||||||||||||||:.|| |:| :..|||||.:|.:......:|:.:.|.|
  Rat   394 CAIAGVLTIALPVPVIVSNFNYFYHRETEGEE-QAQ-YLQVTSCPKIPSSPDLKKSRSASTISKS 456

  Fly   527 DMMDLDDGVEST 538
            |.|::.:||.::
  Rat   457 DYMEIQEGVNNS 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 106/125 (85%)
Ion_trans 226..488 CDD:459842 186/270 (69%)
Kcna2NP_037102.1 Tetramerization domain. /evidence=ECO:0000305|PubMed:11007484 1..125 84/107 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/8 (38%)
BTB_POZ 33..159 CDD:453885 106/125 (85%)
Ion_trans 162..420 CDD:459842 186/270 (69%)
S4-S5 linker. /evidence=ECO:0000305|PubMed:16002579 312..325 11/12 (92%)
Selectivity filter. /evidence=ECO:0000305 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000269|PubMed:7477295 497..499
Blue background indicates that the domain is not in the aligned region.

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