Protein Alignment Sh and Kcna10

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001074609.1
• Gene: Kcna10 / 242151
• MGIID: 3037820
• Length: 511
• Species: Mus musculus
• Alignment Length: 444
• Identity: 277/444 - (62%)
• Similarity: 339/444 - (76%)
• Gaps: 33/444 - (7%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            :||:||::|||||||||||||||:|||||..:|:::||.:||||||||:|||||.|||||||||:
Mouse    86 QRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGK 150

  Fly   162 LRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAA 226
            :|||.|||:|||::||.|||||.:|:::|||||||||:.|..||.|:..|:.||||||||||.||
Mouse   151 IRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAA 215

  Fly   227 RVVAIISVFVILLSIVIFCLETLPEF---KHYKVF---NTTTNGTKIEEDEVPDITDPFFLIETL 285
            |.||::||.|:::||.||||||||||   :..||.   :..||.|.:.:..   .|||||::|:.
Mouse   216 RGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLSQTM---FTDPFFMVEST 277

  Fly   286 CIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDK 350
            ||:||||||.:||:.||:|.:|.:::||:||||:|||||.||.|.:.:|             .:.
Mouse   278 CIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQE-------------TEP 329

  Fly   351 SSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVY 415
            |:.|.|||||||:|||||||||||||||||||||||:||||||||||||||||||||:|||||||
Mouse   330 SAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVY 394

  Fly   416 FAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSN 480
            |||.....|.|.||||.||||||||||||||||.|....|||||:||||||||||||||||||||
Mouse   395 FAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSN 459

  Fly   481 FNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDG 534
            |||||||||:.||.           |.:||.|.:.:........|::.::..:|
Mouse   460 FNYFYHRETENEEK-----------PNIPGELDKILNSMGSRMGSTESLNKTNG 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	88/125 (70%)
		Ion_trans	226..488	CDD:459842	175/267 (66%)
Kcna10	NP_001074609.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..44
		BTB_POZ	86..212	CDD:453885	88/125 (70%)
		Ion_trans	262..467	CDD:459842	151/220 (69%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..511		2/14 (14%)