DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and Kcng1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001074603.1	Gene:	Kcng1 / 241794	MGIID:	3616086	Length:	514	Species:	Mus musculus

Alignment Length:	523	Identity:	155/523 - (29%)
Similarity:	242/523 - (46%)	Gaps:	103/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QRNSLDG--YGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFC------ERVVINVSGLRFE 109
            ||.::.|  |....:|..||:.                    |..|      .:::|||.|:::.
Mouse    31 QRQAIKGVFYRRAQRLRPQDDL--------------------HQSCSLGDRRRQIIINVGGIKYS 75

  Fly   110 TQLRTLNQFPDTLLGDPARRLRY---------FDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRP 165
            ....||::||.|.||.......:         :|...||:||||:..:|..||.:.:: |:||..
Mouse    76 LPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRA-GKLRLL 139

  Fly   166 VNVPLDVFSEEIKFYELGD------------QAINKFRE--DEGFIKEEERPLPDNEKQ------ 210
            ..:....|.||:.::.:.:            |.|.:|.|  :.   :|||.|| |:|.|
Mouse   140 REMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMER---EEEEEPL-DSEDQESEGPS 200

  Fly   211 ----------RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGT 265
                      |::..:.|.|.|....:|.|.:||..:.::.|...:.|||..:..:
Mouse   201 ASEGRLSRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEE--------- 256

  Fly   266 KIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATV 330
              |:.:...:....|::|::|:.||:.|..:||:..|:|..|.|..:.:||::||:||::||  :
Mouse   257 --EQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTL--L 317

  Fly   331 VAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRE 395
            |.....:...|....|..||..      .:|||:|.:|:..:.:|:|||.|||.||.|.:...||
Mouse   318 VDGAASSRRKPSTGNSYLDKVG------LVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTRE 376

  Fly   396 LGLLIFFLFIGVVLFSSAVYFAE-AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVG 459
            .|||:.||.:.:.||:..:|..| ..:||..|.|||..:||||:||||||||||.|....|::|.
Mouse   377 FGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVA 441

  Fly   460 SLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSES 524
            ....::|:|.:|.||..|...|:..|     .|..|.|....:....||..|      ||.||..
Mouse   442 LSSILSGILLMAFPVTSIFHTFSRSY-----LELKQEQERVLIRRAQYLIKT------KSQLSGM 495

  Fly   525 SSD 527
            |.|
Mouse   496 SQD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	28/108 (26%)
		BTB	99..182	CDD:197585	27/91 (30%)
		Ion_trans	274..488	CDD:278921	82/214 (38%)
		Ion_trans_2	403..479	CDD:285168	34/76 (45%)
Kcng1	NP_001074603.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	28/113 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..205		8/28 (29%)
		Ion_trans	227..471	CDD:395416	92/267 (34%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	424..429		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810