Protein Alignment Sh and Kcng2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001177302.1
• Gene: Kcng2 / 240444
• MGIID: 3694646
• Length: 480
• Species: Mus musculus
• Alignment Length: 527
• Identity: 150/527 - (28%)
• Similarity: 238/527 - (45%)
• Gaps: 104/527 - (19%)

  Fly    71 EEGGAGH----GFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLR 131
            |.|.||.    |.|...:|             |:|||.|.|.......|.:.|...|    .|||
Mouse    14 EPGSAGRRGRGGRGARARH-------------VIINVGGCRVRLAWAALARCPLARL----ERLR 61

  Fly   132 Y-------------FDPLRNEYFFDRSRPSFDAILYYYQSG--GRLRRPVNVPLDVFSEEIKFYE 181
            .             :|..|:|:|||||..:|.||:...::|  ..||.|..:   .|.:|:.::.
Mouse    62 ACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCAL---AFRDELAYWG 123

  Fly   182 LGDQAINKF-------REDEGFIKEEERP-----------LPDNEKQR---KVWLLFEYPESSQA 225
            :.:..:.:.       ||:|.......:|           |.....:|   ::..:.|.|.|..|
Mouse   124 IDEARLERCCLRRLRRREEEAAEASAAQPARGPPTSPGRALGSGRLERGRQRLRDVVENPHSGLA 188

  Fly   226 ARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWF 290
            .|:.|.:||..:.::.|..||.|:|:.:           .:.|..|........|::||:|:.||
Mouse   189 GRLFAYVSVAFVAVTAVGLCLSTMPDVR-----------AEEERGECSTKCRNLFVLETVCVAWF 242

  Fly   291 TFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQA 355
            :||..:|.|...:|..|.|..:.:|||:||:|::::|...:|            ..|......:.
Mouse   243 SFEFLLRSLQAESKCAFLRTPLAIIDILAILPFYVSLLAGLA------------AGPTGSKMLER 295

  Fly   356 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFA--E 418
            ..| :||::|.:||..:.:|:|||.||:.||.|::...||.|||:.||.:.:.||:..|:.|  |
Mouse   296 AGL-VLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERE 359

  Fly   419 AGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNY 483
            .|:... |.|:|.::||||::|||||||||.|..:.|::|.....::|:|.:|.||..|...|:.
Mouse   360 LGAHRD-FSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSR 423

  Fly   484 FYHRETDQEEMQSQNFNHVTSCPYL--PGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHP 546
            .|      .|::.|.....:..|.|  ..|.....:.:|.:|.||...:       |.|...:.|
Mouse   424 SY------SELKEQQQRAASPEPALREDSTRDDSTRSASATEDSSQDPE-------TAGAAGSLP 475

  Fly   547 GRSAVAP 553
            ||  |.|
Mouse   476 GR--VGP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	37/161 (23%)
		Ion_trans	226..488	CDD:459842	88/263 (33%)
Kcng2	NP_001177302.1	BTB_POZ	33..127	CDD:453885	29/100 (29%)
		Ion_trans	190..429	CDD:459842	89/269 (33%)