DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcnq5

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001153611.1 Gene:Kcnq5 / 226922 MGIID:1924937 Length:952 Species:Mus musculus


Alignment Length:622 Identity:131/622 - (21%)
Similarity:219/622 - (35%) Gaps:193/622 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 LPKLSSQDEEGG-----------AGHGFGGGPQHFEPIPHDHDFCE---RVVINVSGLRFETQLR 113
            :|:..:..||||           |..|.|||    .|.....|...   ||::|.:..|.:..| 
Mouse     1 MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGG----RPGSGMKDVESGRGRVLLNSAAARGDGLL- 60

  Fly   114 TLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRP-----------VN 167
                    |||..|..|.                         ..||.||..           :.
Mouse    61 --------LLGTRAAALG-------------------------GGGGGLRESRRGKQGARMSLLG 92

  Fly   168 VPLDVFSEE-----IKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAAR 227
            .||...|.:     :|:..:.:...|..          |||        :.|..           
Mouse    93 KPLSYTSSQSCRRNVKYRRVQNYLYNVL----------ERP--------RGWAF----------- 128

  Fly   228 VVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTF 292
               :...||.||  |..||       ...||:|....||:       .:....::|.:.|:.|..
Mouse   129 ---VYHAFVFLL--VFGCL-------ILSVFSTIPEHTKL-------ASSCLLILEFVMIVVFGL 174

  Fly   293 ELTV---------RFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQ 348
            |..:         |:.....:|.|.|....|||.|.:|   .::|.|.|                
Mouse   175 EFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLI---ASIAVVSA---------------- 220

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIG--VVLFS 411
             |:.....:.:.||.:|.:::.|:.::.|.....::||..:.|..:|   ||...:||  |::||
Mouse   221 -KTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKE---LITAWYIGFLVLIFS 281

  Fly   412 SAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPV 476
            |.:.:......|..|.:..||.||..:|:||:||||.||:...|:::.:..|:.|:...|||..:
Mouse   282 SFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGI 346

  Fly   477 IVSNFN---YFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVEST 538
            :.|.|.   ...||:...|:.::...| :..|.:         :..:..|.|..:      ....
Mouse   347 LGSGFALKVQEQHRQKHFEKRRNPAAN-LIQCVW---------RSYAADEKSVSI------ATWK 395

  Fly   539 PGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNG 603
            |.|...|    ..:|     .:::|..|||.....:||           :.::....::|.|:..
Mouse   396 PHLKALH----TCSP-----TKKEQGEASSSKFCSNKQ-----------KFFRVYTSRKQSQKLS 440

  Fly   604 FKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLT 640
            ||::.:....:.|..:|.    .|:.....|.|:.:|
Mouse   441 FKERVRMASPRGQSIKSR----QASVGDRRSPSTDIT 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 23/144 (16%)
Ion_trans 226..488 CDD:459842 70/275 (25%)
Kcnq5NP_001153611.1 Ion_trans 127..359 CDD:459842 69/284 (24%)
Interaction with CALM. /evidence=ECO:0000250|UniProtKB:Q9NR82 371..379 2/8 (25%)
KCNQ_channel 467..654 CDD:460954 3/7 (43%)
Interaction with CALM. /evidence=ECO:0000250|UniProtKB:Q9NR82 541..548
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..617
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 897..952
Blue background indicates that the domain is not in the aligned region.

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