DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnq5

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001153611.1	Gene:	Kcnq5 / 226922	MGIID:	1924937	Length:	952	Species:	Mus musculus

Alignment Length:	623	Identity:	131/623 - (21%)
Similarity:	219/623 - (35%)	Gaps:	195/623 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LPKLSSQDEEGG-----------AGHGFGGGPQHFEPIPHDHDFCE---RVVINVSGLRFETQLR 113
            :|:..:..||||           |..|.|||    .|.....|...   ||::|.:..|.:..|
Mouse     1 MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGG----RPGSGMKDVESGRGRVLLNSAAARGDGLL- 60

  Fly   114 TLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRP-----------VN 167
                    |||..|..|.                         ..||.||..           :.
Mouse    61 --------LLGTRAAALG-------------------------GGGGGLRESRRGKQGARMSLLG 92

  Fly   168 VPLDVFSEE-----IKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAAR 227
            .||...|.:     :|:..:.:...|..          |||        :.|..
Mouse    93 KPLSYTSSQSCRRNVKYRRVQNYLYNVL----------ERP--------RGWAF----------- 128

  Fly   228 VVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTF 292
               :...||.||  |..||       ...||:|....||:       .:....::|.:.|:.|..
Mouse   129 ---VYHAFVFLL--VFGCL-------ILSVFSTIPEHTKL-------ASSCLLILEFVMIVVFGL 174

  Fly   293 ELTV---------RFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQ 348
            |..:         |:.....:|.|.|....|||.|.:|   .::|.|.|
Mouse   175 EFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLI---ASIAVVSA---------------- 220

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIG--VVLFS 411
             |:.....:.:.||.:|.:::.|:.::.|.....::||..:.|..:|   ||...:||  |::||
Mouse   221 -KTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKE---LITAWYIGFLVLIFS 281

  Fly   412 S-AVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVP 475
            | .||..|..::.. |.:..|..||..:|:||:||||..|:...|:::.:..|:.|:...|||..
Mouse   282 SFLVYLVEKDANKE-FSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAG 345

  Fly   476 VIVSNFN---YFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVES 537
            ::.|.|.   ...||:...|:.::...| :..|.:         :..:..|.|..:      ...
Mouse   346 ILGSGFALKVQEQHRQKHFEKRRNPAAN-LIQCVW---------RSYAADEKSVSI------ATW 394

  Fly   538 TPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQN 602
            .|.|...|    ..:|     .:::|..|||.....:||           :.::....::|.|:.
Mouse   395 KPHLKALH----TCSP-----TKKEQGEASSSKFCSNKQ-----------KFFRVYTSRKQSQKL 439

  Fly   603 GFKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLT 640
            .||::.:....:.|..:|.    .|:.....|.|:.:|
Mouse   440 SFKERVRMASPRGQSIKSR----QASVGDRRSPSTDIT 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	17/103 (17%)
		BTB	99..182	CDD:197585	17/98 (17%)
		Ion_trans	274..488	CDD:278921	58/228 (25%)
		Ion_trans_2	403..479	CDD:285168	27/78 (35%)
Kcnq5	NP_001153611.1	Ion_trans	161..359	CDD:278921	57/221 (26%)
		Ion_trans_2	275..349	CDD:285168	25/74 (34%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		KCNQ_channel	473..660	CDD:281513	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..952
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810