Protein Alignment Sh and Kcng3

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_705732.1
• Gene: Kcng3 / 225030
• MGIID: 2663923
• Length: 433
• Species: Mus musculus
• Alignment Length: 443
• Identity: 146/443 - (32%)
• Similarity: 228/443 - (51%)
• Gaps: 54/443 - (12%)

  Fly    99 VVINVSGLRFETQLRTLNQFP----DTLLGDPARR-----LRYFDPLRNEYFFDRSRPSFDAILY 154
            ||:||.|.|:......|..||    ..|.|..:.|     ...:|..||||||||...:|..||.
Mouse    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly   155 YYQSGGRLR-RPVNVPLDVFSEEIKF------------YELGDQA--INKFREDEGFIKEEERPL 204
            |.:..|:|| .|....|..::|.|.:            ..|.|:.  .:.|...:...:|:.||.
Mouse    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHAADELGREQPRPA 140

  Fly   205 PDNEKQRKVWL-----LFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNG 264
            .......:.||     .||.|.||.||:::|.:||..:::|:|:.|..|||:::.....|.:.:
Mouse   141 GPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRAAVADNRSLD- 204

  Fly   265 TKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLAT 329
            .:......|. .:|..:||.:||.|||.|..|||:...||..|.:..:|:||::||.||:|::..
Mouse   205 DRSRYSASPG-REPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLM 268

  Fly   330 VVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMR 394
            .|...|:: .|.:|.|:              |||:|::|:|.:.||:||..|||.||.|||...|
Mouse   269 TVFTGENS-QLQRAGVT--------------LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYR 318

  Fly   395 ELGLLIFFLFIGVVLFSSAVYFAEAG----SENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWG 455
            |:.:|:.|:.:.:.:||:.....|.|    :.|..|.|||.|.||.:::|||||||||.|:.|.|
Mouse   319 EMAMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPG 383

  Fly   456 KIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYL 508
            :|:|.:|.::|::.:|||:..|..:|...||    :.:.:|..::...|..:|
Mouse   384 RILGGVCVVSGIVLLALPITFIYHSFVQCYH----ELKFRSARYSRSLSAEFL 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	43/152 (28%)
		Ion_trans	226..488	CDD:459842	97/265 (37%)
Kcng3	NP_705732.1	BTB_POZ_KCNG3	11..122	CDD:349729	34/110 (31%)
		Ion_trans	210..417	CDD:459842	86/226 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)