DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and shw-3

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001355445.1	Gene:	shw-3 / 191761	WormBaseID:	WBGene00004793	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	171/498 - (34%)
Similarity:	267/498 - (53%)	Gaps:	81/498 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRL 162
            |:::||.|:|.||...||.:.|.|.|......|..:||:.|||||||....|..||.||:: |:|
Worm    27 RIILNVGGVRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRT-GKL 90

  Fly   163 RRPVNVPLDVFSEEIKFYELGD--------QAINKFRE--------DEGFIKEEERPLPDNEK-- 209
            ..|::|...:|.||:|::.|..        ..::..|:        ||..|:.::...|:..|
Worm    91 HYPLDVCGPLFEEELKYWGLDSNECEPCCWMTLSGTRDTQDVLKTLDELDIEVDQTEGPELYKRF 155

  Fly   210 -----------------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET-----LPEF 252
                             :.::|.||:.|.||::|:.:|.||||.::.:|::|||:|     :||.
Worm   156 GWEDDYHNDSLSAWQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLRIPEL 220

  Fly   253 KHYKVFNTTTNGT-------KIEEDEVPDITDPFFL-IETLCIIWFTFELTVRFLACPNKLNFCR 309
            ..:..|:.....|       :|..|:......|.|: |||:|.||||.|:..||.:||::..:.|
Worm   221 APFGNFSRNHRSTSSRIHPAQINIDKANSRPHPTFMYIETICNIWFTIEILARFSSCPSRFEYLR 285

  Fly   310 DVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFK 374
            ..:|:|||:|.:.::|                       |..|:...:.|.|....::|:.|:||
Worm   286 APVNIIDIVATLTFYI-----------------------DLLSSMFGATADLEFFSIIRIMRLFK 327

  Fly   375 LSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE--AGSDSSFFKSIPDGFWWAV 437
            |:.|:.||:||..|.:||.:||.||:|||.:|||:|:|.||:||  ..::.:.|.|||.|.|||:
Worm   328 LTHHNSGLKILMHTFRASAKELMLLVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAI 392

  Fly   438 VTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHV 502
            |||||:||||:.|....|:::||:||:|||||||||||||||||..||.....:.:|..:....:
Worm   393 VTMTTIGYGDITPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVL 457

  Fly   503 TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETH 545
            :.     ..:.||:|.:.:..|:....  ...:|:||.::..|
Worm   458 SM-----DQVAQHVKHAPVRNSNGPTQ--RKNMENTPLVSNNH 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	35/95 (37%)
		BTB	99..182	CDD:197585	34/82 (41%)
		Ion_trans	274..488	CDD:278921	97/216 (45%)
		Ion_trans_2	403..479	CDD:285168	46/77 (60%)
shw-3	NP_001355445.1	BTB_POZ	25..136	CDD:365784	37/109 (34%)
shw-3	NP_001355445.1	Ion_trans	257..444	CDD:366146	95/209 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810