Protein Alignment Sh and kvs-1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001360715.1
• Gene: kvs-1 / 183753
• WormBaseID: WBGene00002242
• Length: 499
• Species: Caenorhabditis elegans
• Alignment Length: 473
• Identity: 149/473 - (31%)
• Similarity: 231/473 - (48%)
• Gaps: 91/473 - (19%)

  Fly    76 GH-----GFGGGPQHFEPIPHDHDFCER------------------VVINVSGLRFETQLRT--- 114
            ||     .||....|.:.|.|..:...|                  :.:||.|..|..::.:
 Worm    27 GHAASRDNFGNSNHHGDEIVHRLNNGRRSEIDEVKPDLVSGAGDTVIKLNVGGTSFRIRISSIFA 91

  Fly   115 ------LNQFPDTLLGDPARRLRYFDPL---RNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPL 170
                  |:.|...   :..:||:..|..   :.||:.:||...||:|..||.| |:|.||::|..
 Worm    92 RSADEKLSAFAQL---NHEQRLQACDAFLMPQEEYYLERSAVLFDSIFKYYIS-GQLHRPLDVCP 152

  Fly   171 DVFSEEIKFYELGD--------QAINKFREDEGFI--KEEERPLPDNEKQRKVWLLFEYPESSQA 225
            ..|:.|:.::::.|        :..|.....|..:  ||::..|.|...:.::....| .:.|..
 Worm   153 TEFATELAYWKINDGLMSNCCWRGYNMSPSLEELVAPKEKKIELHDRSMRSRIHQFCE-GDGSLF 216

  Fly   226 ARVVAIISVFVILLSIVIFCLETLPEF---------KHYKVFN---TTTNGT--KIEEDEVPDIT 276
            :.:....|:..:|:|::...|.::.||         |..::.|   ...|||  .:|.:.:  |.
 Worm   217 STLFTFGSITFVLISVIGLVLGSIHEFQVPIYKKGGKSERISNWSIADQNGTDSSVENENI--IW 279

  Fly   277 DP---FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATV-----VAE 333
            :|   |..:||:||||||.|..||....||:..|...:||::|:|||||:::.|...     ||.
 Worm   280 EPHPIFGYVETVCIIWFTVEFIVRLAVTPNRFQFLVGIMNIVDMIAIIPFYLELGLALFGIDVAS 344

  Fly   334 EEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGL 398
            ..|...                 :|.::||:|::||.||.||.|:|.|::....|||:|.|:||:
 Worm   345 LSDIKG-----------------ALLVVRVLRVLRVVRILKLGRYSSGMRTFALTLKSSARQLGM 392

  Fly   399 LIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCA 463
            :...|..|||.||:.:||.|...:::.|.|||.|||||:||||||||||..||.|.||::.|...
 Worm   393 MGMVLSTGVVFFSTLLYFVEKDEKDTPFTSIPAAFWWAIVTMTTVGYGDYVPVTVPGKLIASGAI 457

  Fly   464 IAGVLTIALPVPVIVSNF 481
            |:|||.:|||:.:||.||
 Worm   458 ISGVLVLALPITIIVDNF 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	35/165 (21%)
		Ion_trans	226..488	CDD:459842	106/278 (38%)
kvs-1	NP_001360715.1	BTB_POZ_Kv	73..163	CDD:349626	26/93 (28%)
		Ion_trans	279..475	CDD:459842	91/212 (43%)