DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and kvs-2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001256236.1	Gene:	kvs-2 / 183120	WormBaseID:	WBGene00007862	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	150/538 - (27%)
Similarity:	247/538 - (45%)	Gaps:	101/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QQQHQKEQLEQKEE---QKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQ 84
            |:.|..::|:.:|.   |....||::..|...:                             |..
Worm    59 QEPHYGKRLQAEENAAVQAASMERRVAFRPPPI-----------------------------GES 94

  Fly    85 HFEPIPHDH----DFCERVVINVSG----LRFETQLRTLNQFPDTLLGDPARRLRY---FDPLRN 138
            ....|.||.    |...|  :||.|    :|.|.......:..:.|......||:.   ||....
Worm    95 RSTTITHDSGSNADTYMR--LNVGGKSYYVRAELYTSEWTRMHELLDSSHEERLKMVDGFDSKTG 157

  Fly   139 EYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFRE--DEGFIKEEE 201
            ||:.:|:....|.::.::.:|. |.:|.||.::.|.||::::::....::...:  .|..:::..
Worm   158 EYYLERNAKLTDHVMDFFVTGS-LHKPQNVCVERFKEELEYWKIKPDQLSTCCQIPSEHHVRKLS 221

  Fly   202 RPLPDNE--------------KQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEF 252
            |....||              .:..:|...|.|:||..|.|.|::|||.:..|:|...|.::|||
Worm   222 RGTSFNEDDYVTDFDGACFAGPRLAMWKFLEDPQSSVFAAVFALLSVFFVFASVVGLILGSMPEF 286

  Fly   253 K-------HYKVFNTTTN----GTKI--EEDEVPD---------ITD----PFFLIETLCIIWFT 291
            :       .|.|.:..:.    |.|.  ::|..|:         .||    |..::|.:||.|||
Worm   287 QADSSNAATYHVMHVRSRPNDYGNKFGNDDDVAPNELLKDFVYKPTDSPNLPLTILEYICIGWFT 351

  Fly   292 FELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAM 356
            ||..|||...|.|..|.:..:|:||:..|:|:::.:.           ||...|..:.|....||
Worm   352 FEYLVRFTIYPRKRQFVKKTLNIIDLSTILPFYLEIC-----------LPLFGVESRLKEFTGAM 405

  Fly   357 SLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGS 421
              .::||:|::|:.|:|||:|:|..||..|.||::|:.||.:|..||..|:|.||:.:|:.|...
Worm   406 --LVVRVLRVLRMARVFKLARYSTSLQTFGHTLQSSITELSMLSMFLITGIVFFSTIMYYLEKDE 468

  Fly   422 DSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 486
            ..:.|.|||.|.||.||||.||||||.:||...||:|.:..:|.|::.:|.|:.:||..|.....
Worm   469 PHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGKLVATSTSICGIIVLAFPISMIVEKFATAQQ 533

  Fly   487 RETDQEEMQSQNFNHVTS 504
            |..:.:::|....:.|.:
Worm   534 RAIEDQQIQQAQMSAVAN 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	22/94 (23%)
		BTB	99..182	CDD:197585	22/89 (25%)
		Ion_trans	274..488	CDD:278921	84/226 (37%)
		Ion_trans_2	403..479	CDD:285168	34/75 (45%)
kvs-2	NP_001256236.1	BTB_POZ_Kv	111..199	CDD:349626	23/90 (26%)
kvs-2	NP_001256236.1	Ion_trans	329..535	CDD:366146	84/218 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910