DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and shk-1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_871935.1	Gene:	shk-1 / 174536	WormBaseID:	WBGene00014261	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	521	Identity:	214/521 - (41%)
Similarity:	317/521 - (60%)	Gaps:	63/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QQQQHQKEQLEQKEEQKKIAERKLQLREQQLQ---------------------RNSLDGYGSLPK 65
            ||:..:||:.:..:...:..|:.|.:..::.|                     |:....:|...:
Worm    25 QQKNKEKEEWKWAQSLARRLEQVLNVHPEKYQNGCSSQRPSRQPSPVEQLAPIRSHSADFGRAAE 89

  Fly    66 LSSQDEEGGAGHGFGGG--------PQHFEP---IPHDHDFCERVV-INVSGLRFETQLRTLNQF 118
            ::|.:.|.|.|.....|        ||...|   ....|.:.:::| |||||:||:|...||:::
Worm    90 MASGNSEEGKGMLLRNGDDRIRLPSPQRGTPDTSSTQGHPYTDQIVTINVSGMRFQTFESTLSRY 154

  Fly   119 PDTLLGDPARRLRYFDPLRNEYFFDRSRPS------------FDAILYYYQSGGRLRRPVNVPLD 171
            |::||||..:|..:|....||:||||.|.:            |::|||.||||||::||..||:|
Worm   155 PNSLLGDRNKRQHFFVSDTNEFFFDRHRTTSSSFTFEIRNYLFESILYIYQSGGRVKRPEIVPID 219

  Fly   172 VFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFV 236
            :|.:|::|:::||..:.:|...||:.|.:|..:|:|:.|||:|.|.|||:||.:||::|.||:.|
Worm   220 IFLKEMRFFQMGDDLLEEFWIAEGYEKPKEVMMPNNKTQRKIWELMEYPDSSLSARIIAFISIAV 284

  Fly   237 ILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLAC 301
            |.|||:.||.||:|.....|..|.:.....::|.:....: |||.||.:||:|||.||.:||::|
Worm   285 IALSIISFCWETVPSDIEEKPINNSATAELLDEMDEKHYS-PFFWIELMCILWFTIELILRFISC 348

  Fly   302 PNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRL 366
            |.|:.|...|:|:||.:||.|:|:.....     ||            ..||.:||.|:|||:||
Worm   349 PCKVTFATSVLNIIDFVAIAPFFVNFFFA-----DT------------SKSNSSMSFAVLRVLRL 396

  Fly   367 VRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPD 431
            |||||:|||||||.||||||:|.::|::|..|||||:.|.:|||:|.:||||.|..:|.|.|||.
Worm   397 VRVFRVFKLSRHSVGLQILGKTFRSSVQEFCLLIFFMAIALVLFASGMYFAEQGEPNSKFTSIPA 461

  Fly   432 GFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQS 496
            .||:.:||||||||||:.|:..:||:||.:||:.||||:|||||:||:||.:||.:|.....|:|
Worm   462 SFWFVLVTMTTVGYGDLVPLSPFGKVVGGMCAMIGVLTLALPVPIIVANFKHFYRQENRLASMKS 526

  Fly   497 Q 497
            :
Worm   527 K 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	45/100 (45%)
		BTB	99..182	CDD:197585	43/95 (45%)
		Ion_trans	274..488	CDD:278921	113/213 (53%)
		Ion_trans_2	403..479	CDD:285168	44/75 (59%)
shk-1	NP_871935.1	BTB	135..238	CDD:197585	45/102 (44%)
		BTB_2	135..238	CDD:280393	45/102 (44%)
		Ion_trans	318..519	CDD:278921	113/218 (52%)
		Ion_trans_2	432..504	CDD:285168	41/71 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1034
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128570
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1136
Isobase	1	0.950	-	0	Normalized mean entropy	S3104
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		oto18327
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930