Protein Alignment Sh and KCNG3

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_579875.1
• Gene: KCNG3 / 170850
• HGNCID: 18306
• Length: 436
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 145/450 - (32%)
• Similarity: 231/450 - (51%)
• Gaps: 65/450 - (14%)

  Fly    99 VVINVSGLRFETQLRTLNQFP----DTLLGDPARR-----LRYFDPLRNEYFFDRSRPSFDAILY 154
            ||:||.|.|:......|..||    ..|.|..:.|     ...:|..||||||||...:|..||.
Human    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly   155 YYQSGGRLR-RPVNVPLDVFSEEIKF------------YELGDQAINKF----REDEGFI-KEEE 201
            |.:..|:|| .|....|..::|.|.:            ..|.|:..:.:    .::.|.: ::|.
Human    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEA 140

  Fly   202 RPLPDNEKQRKVWL-----LFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTT 261
            ||........:.||     .||.|.||.||:::|.:||..:::|:|:.|..|||:::     |..
Human   141 RPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWR-----NAA 200

  Fly   262 TNGTKIEE----DEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIP 322
            .:...:::    ...|. .:|..:||.:||.|||.|..|||:...||..|.:..:|:||::||.|
Human   201 ADNRSLDDRSRYSAGPG-REPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITP 264

  Fly   323 YFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGR 387
            |:|::...|...|:: .|.:|.|:              |||:|::|:|.:.||:||..|||.||.
Human   265 YYISVLMTVFTGENS-QLQRAGVT--------------LRVLRMMRIFWVIKLARHFIGLQTLGL 314

  Fly   388 TLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSD----SSFFKSIPDGFWWAVVTMTTVGYGDM 448
            |||...||:.:|:.|:.:.:.:||:.....|.|.|    :..|.|||...||.:::|||||||||
Human   315 TLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDM 379

  Fly   449 RPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYL 508
            .|:.|.|:|:|.:|.::|::.:|||:..|..:|...||    :.:.:|..::...|..:|
Human   380 YPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH----ELKFRSARYSRSLSTEFL 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	34/109 (31%)
		BTB	99..182	CDD:197585	32/104 (31%)
		Ion_trans	274..488	CDD:278921	84/217 (39%)
		Ion_trans_2	403..479	CDD:285168	31/79 (39%)
KCNG3	NP_579875.1	BTB_POZ_KCNG3	11..122	CDD:349729	34/110 (31%)
		Ion_trans	219..420	CDD:395416	84/219 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	373..378		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810