DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcns1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_032461.2	Gene:	Kcns1 / 16538	MGIID:	1197019	Length:	497	Species:	Mus musculus

Alignment Length:	517	Identity:	153/517 - (29%)
Similarity:	247/517 - (47%)	Gaps:	109/517 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLG--------DPARRL-RYFDPLRNEYFFDRS 145
            |.|    |.:.:||.|:|.....|.|.:||.|.||        :.|||| ..:|...:|::|||.
Mouse    16 PRD----EALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRH 76

  Fly   146 RPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI----------------NKFREDE 194
            ...|..:|::|:: |.|.....:.:..|.:|..::.||:.|:                ..:.||.
Mouse    77 PGFFLGLLHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVARPRAWDEDS 140

  Fly   195 GFIKEEERPLPD-----------------NEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIV 242
            ......: |.||                 ...:|::||..|.|..|..:::.:.:|:.|:|.||.
Mouse   141 DAPSSVD-PCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIA 204

  Fly   243 IFCLETLPEFKHYK---VFNTTTNGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPN 303
            ..|:.:|||::..:   .......|...|  ||.|  ||.. .:|..||.||:||::.|.|..|:
Mouse   205 AMCIHSLPEYQAREAAAAVAAVAAGRSAE--EVRD--DPVLRRLEYFCIAWFSFEVSSRLLLAPS 265

  Fly   304 KLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS--LAILRVIRL 366
            ..||....:|:|||::::|:::||            |..|.:..|..:|.:.:.  ..:::|.||
Mouse   266 TRNFFCHPLNLIDIVSVLPFYLTL------------LAGAALGDQRGASGEELGDLGKVVQVFRL 318

  Fly   367 VRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPD 431
            :|:||:.||:|||.||:.||.|||.|.||:|:|:.:|.:||.:||...|.||  .::..|.:||.
Mouse   319 MRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE--EENEGFHTIPA 381

  Fly   432 GFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQS 496
            .:||..|:||||||||:.|..|.||:..|.|.:.|:|.:|||:.:|.:.|::||.|:
Mouse   382 CWWWGTVSMTTVGYGDVVPETVGGKLAASGCILGGILVVALPITIIFNKFSHFYRRQ-------- 438

  Fly   497 QNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTE---------THPGRS 549
                                |....:..||...:.:|.:.|..|:::         :..|||
Mouse   439 --------------------KALEAAVRSSGQREFEDLLSSVDGVSDVSLETSRDTSQEGRS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	29/96 (30%)
		BTB	99..182	CDD:197585	27/91 (30%)
		Ion_trans	274..488	CDD:278921	86/216 (40%)
		Ion_trans_2	403..479	CDD:285168	34/75 (45%)
Kcns1	NP_032461.2	BTB_POZ	21..126	CDD:365784	30/105 (29%)
		Ion_trans	188..439	CDD:395416	100/296 (34%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	392..397		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..497		3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810