DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnq2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_017171224.1	Gene:	Kcnq2 / 16536	MGIID:	1309503	Length:	937	Species:	Mus musculus

Alignment Length:	260	Identity:	67/260 - (25%)
Similarity:	110/260 - (42%)	Gaps:	46/260 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 IISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELT 295
            |...:|.||  |..|| .|..|...|.:..::.|.             .:::|.:.|:.|..|..
Mouse    94 IYHAYVFLL--VFSCL-VLSVFSTIKEYEKSSEGA-------------LYILEIVTIVVFGVEYF 142

  Fly   296 VRFLAC---------PNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKS 351
            ||..|.         ..:|.|.|....||||:.:|.....||.                    .|
Mouse   143 VRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAA--------------------GS 187

  Fly   352 SNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYF 416
            .....:.:.||.:|.:::.|:.::.|.....::||..:.|..:||....:..|:.::|.|..||.
Mouse   188 QGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYL 252

  Fly   417 AEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNF 481
            ||.| ::..|.:..|..||.::|:||:||||..|....|:::.:...:.||...|||..::.|.|
Mouse   253 AEKG-ENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGF 316

Fly 482 481
Mouse 317 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393
		BTB	99..182	CDD:197585
		Ion_trans	274..488	CDD:278921	56/217 (26%)
		Ion_trans_2	403..479	CDD:285168	26/75 (35%)
Kcnq2	XP_017171224.1	Ion_trans	92..324	CDD:366146	67/260 (26%)
		KCNQ_channel	466..719	CDD:367540
		KCNQ2_u3	734..821	CDD:374697
		KCNQC3-Ank-G_bd	840..933	CDD:371819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810