DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcnd1

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_032449.1 Gene:Kcnd1 / 16506 MGIID:96671 Length:651 Species:Mus musculus


Alignment Length:641 Identity:197/641 - (30%)
Similarity:305/641 - (47%) Gaps:137/641 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.||||...||:::||||||...:.. ::|....||||||....|..:|.:|:: ||
Mouse    40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDAESGEYFFDRDPDMFRHVLNFYRT-GR 102

  Fly   162 LRRPVNVPLDVFSEEIKFYEL-----GDQAINKFR-----------EDEGFIKEEERP-LPDNEK 209
            |..|....:..|.||:.||.|     ||..:.::|           |||...:..|.| ||....
Mouse   103 LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSS 167

  Fly   210 QR-KVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGT---KIEED 270
            .| ::|..||.|.:|.||.|...::.|.|.:|::...:||:|           ..||   ..:|.
Mouse   168 LRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-----------CRGTPRWPSKEQ 221

  Fly   271 EVPD-ITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEE 334
            ...| ....||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.      
Mouse   222 SCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLF------ 280

  Fly   335 EDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLL 399
                 :||          |..:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|
Mouse   281 -----VPK----------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFL 329

  Fly   400 IFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAI 464
            :|.|.:.:::|::.:::||.|:..:.|.|||..||:.:|||||:|||||.|..:.|||.||:|::
Mouse   330 LFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSL 394

  Fly   465 AGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHV---------TSCPYLPGTLGQHMKKSS 520
            :|||.||||||||||||:..||:....::.::|....:         |:..:|     |:.:...
Mouse   395 SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFL-----QYKQNGG 454

  Fly   521 LSESSSDMMDLDDG----VESTPGLTETHP--------------------GRSAVAPFLGAQQQQ 561
            |.:|.|     .||    |.|.....:.|.                    ..:..|..||.:..:
Mouse   455 LEDSGS-----GDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSR 514

  Fly   562 QQPVASS-------LSMSIDKQL-QHPLQQLTQTQLYQQQQQQQQQQQNGFKQQ-QQQTQQQLQQ 617
            ...|:|.       .|....::: :..::....|....:...|:.....|.::. ..||:..|..
Mouse   515 STSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLNA 579

  Fly   618 Q------------------------QSHTINASAAAATSGSGSSG----LTMRHNN 645
            :                        .::|.:.|..::.||.|.||    .|:|:::
Mouse   580 KPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSGGTPNTTLRNSS 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 39/92 (42%)
BTB 99..182 CDD:197585 36/82 (44%)
Ion_trans 274..488 CDD:278921 98/214 (46%)
Ion_trans_2 403..479 CDD:285168 39/75 (52%)
Kcnd1NP_032449.1 Interaction with KCNIP2. /evidence=ECO:0000250 2..20
BTB_POZ 6..143 CDD:365784 41/104 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..164 6/19 (32%)
Ion_trans 185..417 CDD:395416 108/264 (41%)
Selectivity filter. /evidence=ECO:0000250 372..377 3/4 (75%)
DUF3399 447..550 CDD:403174 17/112 (15%)
Mediates dendritic targeting. /evidence=ECO:0000250 474..489 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..585 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..651 9/35 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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