DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna5

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_666095.1 Gene:Kcna5 / 16493 MGIID:96662 Length:602 Species:Mus musculus


Alignment Length:499 Identity:309/499 - (61%)
Similarity:359/499 - (71%) Gaps:64/499 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 EQKKIAERKLQLREQQLQRNSLDGYGSLP------------KLSSQDEEGGAGHGFG-----GGP 83
            :.|:.:.|:....|..       |.|..|            :.|::||||....|.|     ..|
Mouse    45 QSKETSPRRRATHEDA-------GQGGRPLPPMPQELPQPRRPSAEDEEGEGDPGLGTVEEDQAP 102

  Fly    84 QHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPS 148
            |....:.|     :||:||:|||||||||.||.|||:||||||.:||||||||||||||||:|||
Mouse   103 QDSGSLHH-----QRVLINISGLRFETQLGTLAQFPNTLLGDPVKRLRYFDPLRNEYFFDRNRPS 162

  Fly   149 FDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKV 213
            ||.|||||||||||||||||.||||::||:||:|||:|:.:||||||||||||:|||.||.||:|
Mouse   163 FDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQV 227

  Fly   214 WLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVF-----------------NTT 261
            ||:|||||||.:||.:||:||.|||:||:.|||||||||:..:..                 |.:
Mouse   228 WLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGS 292

  Fly   262 TNGTKIEEDEVP-----DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAII 321
            .:|.......|.     .:.||||::||.|:|||||||.|||.|||:|..|.|::||:|||:||.
Mouse   293 GSGVLSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIF 357

  Fly   322 PYFITLATVVAEEEDTLNLPKAPVSPQDKSSN--QAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 384
            ||||||.|.:||::           |.....|  |||||||||||||||||||||||||||||||
Mouse   358 PYFITLGTELAEQQ-----------PGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 411

  Fly   385 LGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMR 449
            ||:||:|||||||||||||||||:|||||||||||.:..|.|.||||.|||||||||||||||||
Mouse   412 LGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMR 476

  Fly   450 PVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEE 493
            |:.|.||||||||||||||||||||||||||||||||||||.||
Mouse   477 PITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEE 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 72/87 (83%)
BTB 99..182 CDD:197585 69/82 (84%)
Ion_trans 274..488 CDD:278921 161/215 (75%)
Ion_trans_2 403..479 CDD:285168 64/75 (85%)
Kcna5NP_666095.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..107 15/68 (22%)
BTB 113..207 CDD:197585 75/93 (81%)
BTB_2 113..204 CDD:280393 73/90 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 2/22 (9%)
Ion_trans 305..515 CDD:278921 161/220 (73%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 407..420 10/12 (83%)
Ion_trans_2 429..506 CDD:285168 65/76 (86%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 469..474 4/4 (100%)
PDZ-binding 600..602
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 361 1.000 Domainoid score I948
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48093
OrthoDB 1 1.010 - - D307298at33208
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - LDO PTHR11537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.790

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