DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna4

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_067250.2 Gene:Kcna4 / 16492 MGIID:96661 Length:654 Species:Mus musculus


Alignment Length:579 Identity:321/579 - (55%)
Similarity:409/579 - (70%) Gaps:67/579 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GEDRQHRKKQQQQQQHQ---------------------KEQLEQKEEQKKIAERKLQLREQQLQR 54
            |..|:.|::.::::.|.                     :|..|::|::::..|.:.:.|....:.
Mouse    81 GSRRRRRQRTEKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEE 145

  Fly    55 NSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFP 119
            :..||. |...|..||:.||.|         :..:.:. |.||||||||||||||||::||.|||
Mouse   146 DHGDGC-SYTDLLPQDDGGGGG---------YSSVRYS-DCCERVVINVSGLRFETQMKTLAQFP 199

  Fly   120 DTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGD 184
            :||||||.:|.:|||||||||||||:|||||||||||||||||:||||||.|:|:||:|||:||:
Mouse   200 ETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE 264

  Fly   185 QAINKFREDEGFIKEEE-RPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET 248
            :|:.||||||||::||| |.||:||.::::||||||||||..||.:||:||.|||:|||||||||
Mouse   265 EALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLET 329

  Fly   249 LPEFK-------------HYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLA 300
            ||||:             |.::.| .|:...:|........||||::||:||:||:||..||..|
Mouse   330 LPEFRDDRDLIMALSAGGHSRLLN-DTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA 393

  Fly   301 CPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIR 365
            ||::..|.:::||:|||::|:||||||.|.:|:::...|          ....||||.||||:||
Mouse   394 CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGN----------GQQQQAMSFAILRIIR 448

  Fly   366 LVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIP 430
            |||||||||||||||||||||.||:|||||||||||||||||:|||||||||||...::.|:|||
Mouse   449 LVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIP 513

  Fly   431 DGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQ 495
            |.||||||||||||||||:|:.|.|||||||||||||||||||||||||||||||||||:.|| |
Mouse   514 DAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE-Q 577

  Fly   496 SQNFNHVTSCPYLPGTLGQHMKKSSLSESS-----SDMMDLDDGV-ESTPGLTETHPGR 548
            :|...:..||||||..|   :||...|.||     |:.:::::|| ||..|..|...|:
Mouse   578 TQLTQNAVSCPYLPSNL---LKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGK 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 70/87 (80%)
BTB 99..182 CDD:197585 68/82 (83%)
Ion_trans 274..488 CDD:278921 149/213 (70%)
Ion_trans_2 403..479 CDD:285168 62/75 (83%)
Kcna4NP_067250.2 K_channel_TID 1..>37 CDD:369607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..145 9/63 (14%)
BTB_POZ 177..304 CDD:365784 97/126 (77%)
Ion_trans 307..571 CDD:366146 175/274 (64%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 463..476 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 525..530 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..654 1/4 (25%)
PDZ-binding. /evidence=ECO:0000250 652..654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 361 1.000 Domainoid score I948
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 620 1.000 Inparanoid score I878
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 1 1.000 - - otm44254
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.860

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