DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna3

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_032444.2 Gene:Kcna3 / 16491 MGIID:96660 Length:528 Species:Mus musculus


Alignment Length:501 Identity:327/501 - (65%)
Similarity:382/501 - (76%) Gaps:40/501 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGP-QHFEPIP------HDHDFC-ERVVINVSGLRF 108
            |:..:..|.|..|      .:||.|.|.|||. ..:||:|      .:.|.| ||||||:|||||
Mouse    10 LEPEAAGGGGGDP------PQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRF 68

  Fly   109 ETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVF 173
            ||||:||.|||:||||||.||:||||||||||||||:||||||||||||||||:|||||||:|:|
Mouse    69 ETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF 133

  Fly   174 SEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVIL 238
            ||||:||:||::|:.||||||||::|||||||..:.||:|||||||||||..||.:||:||.|||
Mouse   134 SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVIL 198

  Fly   239 LSIVIFCLETLPEFKHYK---------VFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFEL 294
            :|||||||||||||:..|         ||....|.|..........:||||::||||||||:|||
Mouse   199 ISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFEL 263

  Fly   295 TVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLA 359
            .|||.|||:|..|.|::||:|||:|||||||||.|.:||.:.              :..||||||
Mouse   264 LVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQG--------------NGQQAMSLA 314

  Fly   360 ILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSS 424
            |||||||||||||||||||||||||||:||||||||||||||||||||:|||||||||||...||
Mouse   315 ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSS 379

  Fly   425 FFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET 489
            .|.||||.||||||||||||||||.||.:.|||||||||||||||||||||||||||||||||||
Mouse   380 GFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET 444

  Fly   490 DQEEMQSQNFNHVTSCPYLPGTLGQHMK-KSSLSESSSDMMDLDDG 534
            :.|| |:| :.||.||.:|..:..:..| :|:.:.|.|:.|.:::|
Mouse   445 EGEE-QAQ-YMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEG 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 73/87 (84%)
BTB 99..182 CDD:197585 71/82 (87%)
Ion_trans 274..488 CDD:278921 162/213 (76%)
Ion_trans_2 403..479 CDD:285168 64/75 (85%)
Kcna3NP_032444.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 8/27 (30%)
BTB 59..153 CDD:197585 77/93 (83%)
BTB_2 59..150 CDD:280393 74/90 (82%)
Ion_trans 243..443 CDD:278921 162/213 (76%)
Ion_trans_2 357..434 CDD:285168 65/76 (86%)
Selectivity filter. /evidence=ECO:0000250 397..402 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 526..528
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 361 1.000 Domainoid score I948
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H128570
Inparanoid 1 1.050 620 1.000 Inparanoid score I878
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48093
OrthoDB 1 1.010 - - D307298at33208
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 1 1.000 - - otm44254
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3654
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.910

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