DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna1

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_034725.3 Gene:Kcna1 / 16485 MGIID:96654 Length:495 Species:Mus musculus


Alignment Length:482 Identity:322/482 - (66%)
Similarity:373/482 - (77%) Gaps:43/482 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 GSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGD 125
            ||.|:.:..|                     ||:.|||||||:|||||||||:||.|||:||||:
Mouse    22 GSYPRQADHD---------------------DHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65

  Fly   126 PARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKF 190
            |.:|:||||||||||||||:||||||||||||||||||||||||||:|||||||||||::|:.||
Mouse    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130

  Fly   191 REDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHY 255
            |||||||||||||||:.|.||:|||||||||||..|||:||:||.|||:||||||||||||.|..
Mouse   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195

  Fly   256 KVFNTT----TNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVID 316
            |.|..|    .|.|.|....:  .|||||::||||||||:|||.|||.|||:|.:|.:::||.||
Mouse   196 KDFTGTIHRIDNTTVIYTSNI--FTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258

  Fly   317 IIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKG 381
            |:|||||||||.|.:||:|.            ::...||.|||||||||||||||||||||||||
Mouse   259 IVAIIPYFITLGTEIAEQEG------------NQKGEQATSLAILRVIRLVRVFRIFKLSRHSKG 311

  Fly   382 LQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYG 446
            |||||:||||||||||||||||||||:|||||||||||....|.|.||||.||||||:|||||||
Mouse   312 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYG 376

  Fly   447 DMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGT 511
            ||.||.:.|||||||||||||||||||||||||||||||||||:.|| |:| ..||:| |.|...
Mouse   377 DMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEE-QAQ-LLHVSS-PNLASD 438

  Fly   512 LGQHMKKSSLSESSSDMMDLDDGVEST 538
             ....::||.:.|.|:.|::::.:.::
Mouse   439 -SDLSRRSSSTISKSEYMEIEEDMNNS 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 75/87 (86%)
BTB 99..182 CDD:197585 72/82 (88%)
Ion_trans 274..488 CDD:278921 160/213 (75%)
Ion_trans_2 403..479 CDD:285168 62/75 (83%)
Kcna1NP_034725.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 85/126 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 3/7 (43%)
BTB_POZ 37..163 CDD:365784 107/125 (86%)
Ion_trans 166..418 CDD:366146 189/265 (71%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 11/12 (92%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 361 1.000 Domainoid score I948
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 620 1.000 Inparanoid score I878
Isobase 1 0.950 - 0 Normalized mean entropy S3104
OMA 1 1.010 - - QHG48093
OrthoDB 1 1.010 - - D307298at33208
OrthoFinder 1 1.000 - - FOG0000074
OrthoInspector 1 1.000 - - otm44254
orthoMCL 1 0.900 - - OOG6_101149
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3654
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.860

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