DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcna1

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_034725.3 Gene:Kcna1 / 16485 MGIID:96654 Length:495 Species:Mus musculus


Alignment Length:482 Identity:323/482 - (67%)
Similarity:374/482 - (77%) Gaps:43/482 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 GSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGD 125
            ||.|:.:..|                     ||:.|||||||:|||||||||:||.|||:||||:
Mouse    22 GSYPRQADHD---------------------DHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65

  Fly   126 PARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKF 190
            |.:|:||||||||||||||:||||||||||||||||||||||||||:|||||||||||::|:.||
Mouse    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130

  Fly   191 REDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHY 255
            |||||||||||||||:.|.||:|||||||||||..|||:||:||.|||:||||||||||||.|..
Mouse   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195

  Fly   256 KVFNTT----TNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVID 316
            |.|..|    .|.|.|....:  .|||||::||||||||:|||.|||.|||:|.:|.:::||.||
Mouse   196 KDFTGTIHRIDNTTVIYTSNI--FTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258

  Fly   317 IIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKG 381
            |:|||||||||.|.:||:|.            ::...||.|||||||||||||||||||||||||
Mouse   259 IVAIIPYFITLGTEIAEQEG------------NQKGEQATSLAILRVIRLVRVFRIFKLSRHSKG 311

  Fly   382 LQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYG 446
            |||||:||||||||||||||||||||:|||||||||||....|.|.|||||||||||:|||||||
Mouse   312 LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYG 376

  Fly   447 DMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGT 511
            ||.||.:.|||||||||||||||||||||||||||||||||||:.|| |:| ..||:| |.|...
Mouse   377 DMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEE-QAQ-LLHVSS-PNLASD 438

  Fly   512 LGQHMKKSSLSESSSDMMDLDDGVEST 538
             ....::||.:.|.|:.|::::.:.::
Mouse   439 -SDLSRRSSSTISKSEYMEIEEDMNNS 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 107/125 (86%)
Ion_trans 226..488 CDD:459842 190/265 (72%)
Kcna1NP_034725.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 85/126 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 3/7 (43%)
BTB_POZ 37..163 CDD:453885 107/125 (86%)
Ion_trans 166..418 CDD:459842 190/265 (72%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 11/12 (92%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
Blue background indicates that the domain is not in the aligned region.

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