Protein Alignment Sh and shaker

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_310869.6
• Gene: shaker / 1272004
• VectorBaseID: AGAMI1_004386
• Length: 643
• Species: Anopheles gambiae
• Alignment Length: 678
• Identity: 501/678 - (73%)
• Similarity: 528/678 - (77%)
• Gaps: 108/678 - (15%)

  Fly    26 HQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIP 90
            |::.:.:..:.|....:|.|.:              ||||||||||||||.||||||..||||||
Mosquito    26 HKERRHDNTQSQSGSNDRALNM--------------SLPKLSSQDEEGGAAHGFGGGHTHFEPIP 76

  Fly    91 HDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYY 155
            ||||||||||||||||||||||||||||||||||||.|||||||||||||||||:||||||||||
Mosquito    77 HDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPDRRLRYFDPLRNEYFFDRNRPSFDAILYY 141

  Fly   156 YQSG-GRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEY 219
            |||| ||||||||||||||||||||||||:||.||||||||||||||:|||.||.||||||||||
Mosquito   142 YQSGSGRLRRPVNVPLDVFSEEIKFYELGEQATNKFREDEGFIKEEEKPLPSNENQRKVWLLFEY 206

  Fly   220 PESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIET 284
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   207 PESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIET 271

  Fly   285 LCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQD 349
            :|||||||||:||||||||||||.|||||:|||||||||||||||||||||||||||||||||||
Mosquito   272 ICIIWFTFELSVRFLACPNKLNFFRDVMNIIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQD 336

  Fly   350 KSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAV 414
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   337 KSTNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAV 401

  Fly   415 YFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVS 479
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   402 YFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVS 466

  Fly   480 NFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTET 544
            ||||||||||||||||||||||||||||||||||||:||:||||||||||||:||||:||||...
Mosquito   467 NFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHLKKTSLSESSSDMMDLEDGVETTPGLLGE 531

  Fly   545 HPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNGFKQQQQ 609
               ::.:.|||||                         .||      .:||.||||||..|
Mosquito   532 ---QNRMVPFLGA-------------------------HLT------DKQQLQQQQQNCCK---- 558

  Fly   610 QTQQQLQQQQSH------------------------------------------TINASAAAATS 632
                    |.|:                                          .:..:......
Mosquito   559 --------QPSNGGGGGGGGLGGGGGVGSGGGGGGGVGDIGGGLGIGGGSGAGGVVGGAVGGVAG 615

  Fly   633 GSGSSG-----LTMRHNNALAVSIETDV 655
            |:||.|     |..|||:||||||||||
Mosquito   616 GAGSIGGTNNNLQQRHNSALAVSIETDV 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	118/126 (94%)
		Ion_trans	226..488	CDD:459842	256/261 (98%)
shaker	XP_310869.6	None