DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnd1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001099218.1	Gene:	Kcnd1 / 116695	RGDID:	621364	Length:	650	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	166/426 - (38%)
Similarity:	242/426 - (56%)	Gaps:	63/426 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.||||...||:::||||||...:.. ::|....||||||....|..:|.:|:: ||
  Rat    40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDAESGEYFFDRDPDMFRHVLNFYRT-GR 102

  Fly   162 LRRPVNVPLDVFSEEIKFYEL-----GDQAINKFR-----------EDEGFIKEEERP-LPDNEK 209
            |..|....:..|.||:.||.|     ||..:.::|           |||...:..|.| ||....
  Rat   103 LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSS 167

  Fly   210 QR-KVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNG-----TKIE 268
            .| ::|..||.|.:|.||.|...::.|.|.:|::...:||:|           ..|     ||.:
  Rat   168 LRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-----------CRGPARWPTKEQ 221

  Fly   269 E--DEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVV 331
            .  |..|   ..||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.
  Rat   222 PCGDRFP---TAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLF--- 280

  Fly   332 AEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMREL 396
                    :||          |..:|.|.: .:|:.|||||||.||||:||:|||.|||:...||
  Rat   281 --------VPK----------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 326

  Fly   397 GLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSL 461
            |.|:|.|.:.:::|::.:::||.|:..:.|.|||..||:.:|||||:|||||.|..:.|||.||:
  Rat   327 GFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391

  Fly   462 CAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            |:::|||.||||||||||||:..||:....::.::|
  Rat   392 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	39/92 (42%)
		BTB	99..182	CDD:197585	36/82 (44%)
		Ion_trans	274..488	CDD:278921	97/213 (46%)
		Ion_trans_2	403..479	CDD:285168	39/75 (52%)
Kcnd1	NP_001099218.1	BTB_POZ	6..143	CDD:365784	41/104 (39%)
		Ion_trans	185..417	CDD:395416	109/267 (41%)
		DUF3399	447..550	CDD:403174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810