DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnq3

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_690887.2	Gene:	Kcnq3 / 110862	MGIID:	1336181	Length:	873	Species:	Mus musculus

Alignment Length:	389	Identity:	90/389 - (23%)
Similarity:	153/389 - (39%)	Gaps:	99/389 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 RPLP-DNEKQRKV-WLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNG 264
            ||:. :|.|.|:: .|:::..|..:...::....||:|:|..:|  |..|..||.|:    |.:|
Mouse    96 RPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLI--LAVLTTFKEYE----TVSG 154

  Fly   265 TKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLA----CPNK-----LNFCRDVMNVIDIIAI 320
                        |...|:||..|..|..|..:|..|    |..|     |.|.|..:.::||
Mouse   155 ------------DWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDI--- 204

  Fly   321 IPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAI-LRVIRLVRVFRIFKLSRHSKGLQI 384
               |:.:|:|                |.....||...||. ||.:|.:::.|:.::.|.....::
Mouse   205 ---FVLIASV----------------PVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKL 250

  Fly   385 LGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE--------AGSD-SSFFKSIPDGFWWAVVTM 440
            ||..:.|..:||....:..|:.::|.|..||..|        .|.: ...|::..|..||.::|:
Mouse   251 LGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITL 315

  Fly   441 TTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQN------- 498
            .|:||||..|....|:::.:..::.||...|||..::.|........:..|:..:.:.
Mouse   316 ATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELI 380

  Fly   499 ----------------------FNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVE-STP 539
                                  :..|.|.|:        .:|..|..::|..:.|.|.|. |.|
Mouse   381 QAAWRYYATNPNRLDLVATWRFYESVVSFPF--------FRKEQLEAAASQKLGLLDRVRLSNP 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393
		BTB	99..182	CDD:197585
		Ion_trans	274..488	CDD:278921	59/232 (25%)
		Ion_trans_2	403..479	CDD:285168	24/84 (29%)
Kcnq3	NP_690887.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Ion_trans	140..364	CDD:278921	66/261 (25%)
		Ion_trans_2	270..354	CDD:285168	24/83 (29%)
		Selectivity filter. /evidence=ECO:0000250	317..322		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:O43525	357..538		12/88 (14%)
		KCNQ_channel	453..657	CDD:281513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..873
		KCNQC3-Ank-G_bd	781..867	CDD:288784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810