Protein Alignment Sh and kcnd2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_012815411.2
• Gene: kcnd2 / 105946842
• XenbaseID: XB-GENE-952449
• Length: 627
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 183/596 - (30%)
• Similarity: 294/596 - (49%)
• Gaps: 123/596 - (20%)

  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLR 163
            :|:||||.||:|...||.::||||||...|.. :|:....||||||....|..||.:|:: |||.
 Frog    43 IVLNVSGTRFQTWRNTLERYPDTLLGSTERDF-FFNQDSGEYFFDRDPDIFRHILNFYRT-GRLH 105

  Fly   164 RPVNVPLDVFSEEIKFYE-----LGDQAINKFRE----------DEGFIKEEERPLPDNEKQRKV 213
            .|.:..:..:.||:.|:.     :||....::::          |:....:.|.|||....::|:
 Frog   106 YPRHECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERLLDDADENKAEGPLPPMSARQKM 170

  Fly   214 WLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDP 278
            |..||.|.:|..|.|...::.|.|.:|::...:||:|              ..|....:.::  |
 Frog   171 WRAFENPHTSTLALVFYYVTGFFIAVSVIANVVETVP--------------CGISPGSLREL--P 219

  Fly   279 --------FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEE 335
                    ||.::|.|::.||.|..:|.:|.|::..|.|.||::||::||:||:|.|.
 Frog   220 CGERYALAFFCLDTACVMIFTVEYLLRLVAAPSRYRFVRSVMSIIDVVAIMPYYIGLV------- 277

  Fly   336 DTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLI 400
                          .::|:.:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:
 Frog   278 --------------MTNNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 327

  Fly   401 FFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIA 465
            |.|.:.:::|::.:::||.||.||.|.|||.|||:.:|||||:|||||.|..:.|||.||:|:::
 Frog   328 FSLTMAIIIFATVMFYAEKGSLNSRFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 392

  Fly   466 GVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMD 530
            |||.||||||||||||:..||:....::.::|....:.           .::.:....:::.:..
 Frog   393 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKTRLA-----------RIRLAKSGSANAYLQS 446

  Fly   531 LDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQ 595
            ..:|:     |.|...|.|          :::||:.|....:...|..|.|..|.:|..::...:
 Frog   447 KRNGL-----LNEALQGSS----------EEEQPLVSKSGSTFATQHHHLLHCLEKTTNHEFVDE 496

  Fly   596 QQ-------------------QQQQNGF---KQQQQQTQ------------QQLQQQQSHTINAS 626
            |.                   ..|.|.|   ::.::..:            :.||:..:..|...
 Frog   497 QTFEDNCMEVSTINKLHSPSLSSQNNSFCCSRRNRKNVRIPNANAPTCSQHESLQELSAIQIQCM 561

  Fly   627 AAAATSGSGSS 637
            ..|..|.|.||
 Frog   562 ERATLSNSRSS 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	47/138 (34%)
		Ion_trans	226..488	CDD:459842	109/269 (41%)
kcnd2	XP_012815411.2	BTB_POZ	6..144	CDD:453885	37/102 (36%)
		Ion_trans	183..414	CDD:459842	108/268 (40%)
		DUF3399	470..542	CDD:463381	9/71 (13%)