Protein Alignment Sh and kcnv2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_002934230.1
• Gene: kcnv2 / 100498412
• XenbaseID: XB-GENE-940169
• Length: 562
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 151/574 - (26%)
• Similarity: 252/574 - (43%)
• Gaps: 99/574 - (17%)

  Fly     6 GLYGLGEDR---QHRKKQQQQQQ----HQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSL 63
            |.|.:.:||   .|....|...:    :..|..|...|:.|.|||         :...|||: ..
 Frog    22 GQYVVDDDRIRLSHNNSNQLFSESSYIYYIEDEEDDVEELKWAER---------EEKRLDGW-KK 76

  Fly    64 PKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLG---- 124
            ..:::|.|.|.......|  :...|..:.....:.:.|||.|..:.........:|.:.:|
 Frog    77 QSIAAQKERGIYEEEQDG--RILSPSYYGKKRRKSLHINVGGTSYRISYGVAASYPKSRIGRLAT 139

  Fly   125 --DPARRLRYFD---PLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGD 184
              |..|:|...|   |..:.|||||....|..|..:|::|....|....|.. |.|||.::.:..
 Frog   140 YTDRQRKLDLCDDYSPKEDVYFFDRDPAIFHHIYNFYRTGVLWVRDELCPRS-FLEEINYWGVRV 203

  Fly   185 QAINK-----FREDEGFIKEE---------ERPLPDNEK----------QRKVWLLFEYPESSQA 225
            :...:     |.|.:..:.|:         |....:||:          :|::|.:.|.|.||..
 Frog   204 KHTPRCCRISFEERQDDLNEQLKVQRELRAEMETEENEELFRGMLYGHLRRRIWNMMEKPFSSVT 268

  Fly   226 ARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWF 290
            |:.:|:.|.|.:|:|:|...|.|:.:.::.......:....:|.            :|||||.:|
 Frog   269 AKAIAVASSFFVLISVVAMTLNTVEDMQYKNAAGLPSGKPYLEH------------VETLCITFF 321

  Fly   291 TFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQA 355
            |.|..:|.::.|:..:|.|.|:|.:|:|||:|.::.:......:||.          ..|.|:..
 Frog   322 TLEYLLRLMSTPDLQHFGRSVLNAVDLIAILPLYLQMLLESFADEDR----------SGKGSSHE 376

  Fly   356 MSL----------AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLF 410
            ..:          .:||::||:|:|||.||:|||.||:..|.||:...:::|.|..|:.:||..|
 Frog   377 HEIEAVGRVGKLGQVLRIMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLFLFIAMGVFSF 441

  Fly   411 SSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVP 475
            |:.||..|.....:.|.|||.|:|||.|:::||||||:.|....|::...||...|::...:|:.
 Frog   442 SAMVYSVEHDVSGTNFTSIPHAWWWAAVSISTVGYGDVYPETHLGRLFAFLCIAFGIILNGMPIS 506

  Fly   476 VIVSNFNYFYHRETDQE-----------EMQSQNFNHVTSC---PYLPGTLGQH 515
            ::.:.|:.:|.:....|           ....:....|.||   |.:|.|.|.:
 Frog   507 ILYNKFSDYYSKLKSYEYTTIRKKRGKVHFTGRAVQKVNSCCCGPPVPNTPGHN 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	36/158 (23%)
		Ion_trans	226..488	CDD:459842	84/271 (31%)
kcnv2	XP_002934230.1	BTB_POZ_KCNV2	110..217	CDD:349732	27/107 (25%)
		Ion_trans	269..520	CDD:459842	84/272 (31%)