Protein Alignment Sh and kcng2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_017950308.2
• Gene: kcng2 / 100497537
• XenbaseID: XB-GENE-954003
• Length: 489
• Species: Xenopus tropicalis
• Alignment Length: 440
• Identity: 136/440 - (30%)
• Similarity: 219/440 - (49%)
• Gaps: 60/440 - (13%)

  Fly    94 DFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRY---------FDPLRNEYFFDRSRPSF 149
            |....|:|||.|:::.....||...|.|.||.......|         :|...||:||||:..:|
 Frog    58 DRTRHVIINVGGIKYRIPWTTLENCPLTRLGKLKTCNNYDEIMDVCDDYDINCNEFFFDRNPCAF 122

  Fly   150 DAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAIN-----------------KFREDEGFI 197
            ..|:.:. :.|:||....:....|.||:.::.:.::.:.                 |..|.|..|
 Frog   123 RTIMTFL-AAGKLRILREMCALSFQEELIYWGIEEEQLEWCCLRKLQQKEEELAEAKMYEGESGI 186

  Fly   198 KEE--ERPLPDNEK----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYK 256
            ..|  :..|.|:.:    .:.:..:.|.|.|....::.|.:||..:.::.|..|:.|:|:|:.
 Frog   187 SNENSQSALQDSGRLAQCMKHLRDMVENPHSGIPGKIFACLSVSFVAITAVSLCISTMPDFRD-- 249

  Fly   257 VFNTTTNGTKIEED--EVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIA 319
                       |||  |........|::||:|:.||:.|..:||:...:|..|.|..:|:|||:|
 Frog   250 -----------EEDRGECSQKCYDIFVLETVCVAWFSLEFVLRFIQAESKCVFLRTPLNMIDIMA 303

  Fly   320 IIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 384
            |:||:|||..      |.|:..|...:..:......:   :|||:|.:|:..:.:|:|||.|||.
 Frog   304 ILPYYITLIV------DALSGGKTGGAGNNYLEKVGL---VLRVLRALRILYVMRLARHSLGLQT 359

  Fly   385 LGRTLKASMRELGLLIFFLFIGVVLFSSAVYFA--EAGSENSFFKSIPDAFWWAVVTMTTVGYGD 447
            ||.|::...||.|||:.||.:.:.|||..||.|  |.|::.. |.|||.::||||::||||||||
 Frog   360 LGLTVRRCTREFGLLLLFLCVAMALFSPLVYLAENELGAKQE-FTSIPGSYWWAVISMTTVGYGD 423

  Fly   448 MTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            |.|..:.|::|.....::|:|.:|.||..|...|:..|....:|::..|:
 Frog   424 MVPRSIPGQVVALSSILSGILLMAFPVTSIFHTFSRSYTELKEQQQRASR 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	36/157 (23%)
		Ion_trans	226..488	CDD:459842	96/265 (36%)
kcng2	XP_017950308.2	BTB_POZ_KCNG1_2	58..171	CDD:349728	28/113 (25%)
		Ion_trans	222..465	CDD:459842	96/265 (36%)