DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcnc1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_031756512.1	Gene:	kcnc1 / 100497402	XenbaseID:	XB-GENE-996920	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	329	Identity:	132/329 - (40%)
Similarity:	183/329 - (55%)	Gaps:	71/329 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 PLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKI 267
            |||           |:|         ||..|:|.||:||..|||||      ::.||...|.|:.
Frog   255 PLP-----------FQY---------VAFASLFFILVSITTFCLET------HETFNPIVNKTET 293

  Fly   268 E------------EDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIA 319
            |            |.|    |:.|. .||.:|::|||||..:|...||||:.|.::.:|:||.:|
Frog   294 EVVGNETQLRFYRESE----TEAFLTYIEGVCVVWFTFEFLMRITFCPNKVEFIKNTLNIIDFVA 354

  Fly   320 IIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHSKGLQ 383
            |:|:::                  .|.....||..|.. |..|||:|.||:.|||||:||..||:
Frog   355 ILPFYL------------------EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLR 401

  Fly   384 ILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSDSSFFKSIPDGFWWAVVT 439
            :||.||:||..|..|||.||.:||::|::.:|:||         :.|:.:.||:||.||||||||
Frog   402 VLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPNDPSASEHTQFKNIPIGFWWAVVT 466

  Fly   440 MTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTS 504
            |||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....::::..:...|:..
Frog   467 MTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 531

  Fly   505 CPYL 508
            .|.|
Frog   532 PPQL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393
		BTB	99..182	CDD:197585
		Ion_trans	274..488	CDD:278921	104/224 (46%)
		Ion_trans_2	403..479	CDD:285168	47/84 (56%)
kcnc1	XP_031756512.1	LLB_putidacin	<49..>94	CDD:411188
kcnc1	XP_031756512.1	Ion_trans	259..516	CDD:395416	125/293 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000